Neuropilin

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{{STRUCTURE_2qqm| PDB=2qqm | SIZE=400| SCENE= |right|CAPTION=Human neuropilin-1, [[2qqm]] }}
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{{STRUCTURE_2qqm| PDB=2qqm | SIZE=400| SCENE= |right|CAPTION=Human neuropilin-1 glycosylated complex with ethylene glycol and Ca+2 ions, [[2qqm]] }}
'''Neuropilin''' (NRP) are neuronal receptors. NRP are co-receptors for semaphorins. There are 2 classes of NRP – NRP-1 and NRP-2. NRP-1 has high affinity for semaphorin-3A while NRP-2 has high affinity for semaphorin-3F.
'''Neuropilin''' (NRP) are neuronal receptors. NRP are co-receptors for semaphorins. There are 2 classes of NRP – NRP-1 and NRP-2. NRP-1 has high affinity for semaphorin-3A while NRP-2 has high affinity for semaphorin-3F.

Revision as of 13:34, 26 October 2011

Template:STRUCTURE 2qqm

Neuropilin (NRP) are neuronal receptors. NRP are co-receptors for semaphorins. There are 2 classes of NRP – NRP-1 and NRP-2. NRP-1 has high affinity for semaphorin-3A while NRP-2 has high affinity for semaphorin-3F.

Contents

3D Structures of Neuropilin

NRP-1

1kex, 2qqi – hNRP-1 B domain – human

2qqm - hNRP-1 A+B domain

2qqn - hNRP-1 B domain + VEGF-blocking antibody

3i97 - hNRP-1 B domains + inhibitor

2orx – rNRP-1 C1+C2 domains – rat

2orz – rNRP-1 + tuftsin peptide

NRP-2

2qqj - hNRP-2 B domain

2qqo - hNRP-2 A+B domains

2qqk, 2qql - hNRP-2 A+B domains + semaphorin-blocking antibody

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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