This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1oko
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:1oko.gif|left|200px]]<br /><applet load="1oko" size=" | + | [[Image:1oko.gif|left|200px]]<br /><applet load="1oko" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1oko, resolution 1.600Å" /> | caption="1oko, resolution 1.600Å" /> | ||
'''CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA LECTIN 1 COMPLEXED WITH GALACTOSE AT 1.6 A RESOLUTION'''<br /> | '''CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA LECTIN 1 COMPLEXED WITH GALACTOSE AT 1.6 A RESOLUTION'''<br /> | ||
| Line 7: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1OKO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa] with GAL, CA, SO4 and MPD as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Glb Binding Site For Chain D'>AC1</scene>. Full crystallographic information is available from [http:// | + | 1OKO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa] with <scene name='pdbligand=GAL:'>GAL</scene>, <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=MPD:'>MPD</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Glb+Binding+Site+For+Chain+D'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OKO OCA]. |
==Reference== | ==Reference== | ||
| Line 27: | Line 27: | ||
[[Category: lectin]] | [[Category: lectin]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 09:59:18 2008'' |
Revision as of 07:59, 3 February 2008
|
CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA LECTIN 1 COMPLEXED WITH GALACTOSE AT 1.6 A RESOLUTION
Overview
The structure of the tetrameric Pseudomonas aeruginosa lectin I (PA-IL) in, complex with galactose and calcium was determined at 1.6 A resolution, and, the native protein was solved at 2.4 A resolution. Each monomer adopts a, beta-sandwich fold with ligand binding site at the apex. All galactose, hydroxyl groups, except O1, are involved in a hydrogen bond network with, the protein and O3 and O4 also participate in the co-ordination of the, calcium ion. The stereochemistry of calcium galactose binding is, reminiscent of that observed in some animal C-type lectins. The structure, of the complex provides a framework for future design of anti-bacterial, compounds.
About this Structure
1OKO is a Single protein structure of sequence from Pseudomonas aeruginosa with , , and as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Structural basis of calcium and galactose recognition by the lectin PA-IL of Pseudomonas aeruginosa., Cioci G, Mitchell EP, Gautier C, Wimmerova M, Sudakevitz D, Perez S, Gilboa-Garber N, Imberty A, FEBS Lett. 2003 Dec 4;555(2):297-301. PMID:14644431
Page seeded by OCA on Sun Feb 3 09:59:18 2008
Categories: Pseudomonas aeruginosa | Single protein | Cioci, G. | Gautier, C. | Gilboa-Garber, N. | Imberty, A. | Mitchell, E. | Perez, S. | Wimmerova, M. | CA | GAL | MPD | SO4 | Galactose binding | Lectin
