Tom Sandbox

From Proteopedia

proteopedia linkproteopedia link

Revision as of 00:56, 9 November 2011 (edit) Alan Tom (Talk | contribs) ← Previous diff		Revision as of 00:57, 9 November 2011 (edit) (undo) Alan Tom (Talk | contribs) Next diff →
Line 1:		Line 1:
	[[Image:1ysa.png|left|300px]]		[[Image:1ysa.png|left|300px]]
-	==GCN4 - The Leucine Zipper==	+
	{{STRUCTURE_2zta| PDB=2zta | SCENE= }}		{{STRUCTURE_2zta| PDB=2zta | SCENE= }}
		+
		+	==GCN4 - The Leucine Zipper==
Line 15:		Line 17:
	===Binding===		===Binding===
		+
	====The Leucine Zipper====		====The Leucine Zipper====
		+
	====Binding with DNA====		====Binding with DNA====
		+
		+
		+	===Function===
		+
	==See Also==		==See Also==

---

Revision as of 00:57, 9 November 2011

spinqualitylabelsall models PDB ID 2zta Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
2zta, resolution 1.80Å ()
Non-Standard Residues:
Structural annotation: Resources: UniProt : P03069
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Contents 1 GCN4 - The Leucine Zipper 1.1 Structure 1.2 Binding 1.2.1 The Leucine Zipper 1.2.2 Binding with DNA 1.3 Function 2 See Also 3 Reference

GCN4 - The Leucine Zipper

Blah blah information about leucine zipper GCN4.

spinqualitylabelsall models PDB ID 1ysa Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1ysa, resolution 2.90Å ()
Structural annotation: Resources: CATH : 1Ysac00, 1Ysad00 InterPro : Ipr011616, Ipr004827 Pfam : PF00170 SCOP : d1ysac_, d1ysad_ UniProt : P03069
Functional annotation: Cellular component: nucleus Biological process: positive regulation of gene-specific transcription involved in unfolded protein response amino acid biosynthetic process regulation of transcription, DNA-dependent transcription regulation of transcription from RNA polymerase II promoter Molecular function: protein dimerization activity transcription factor activity DNA binding sequence-specific DNA binding
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Structure

GCN4 (PDB 2zta by itself, 1ysa bound to DNA) is a eukaryotic transcription factor first isolated from yeast. It is composed of two identical 52 residue alpha helix chains that grouped together to form a dimer. The dimer binds through interlocking leucine amino acids in the C terminal ends, while pinching in on the major groove of DNA in the N terminal end. The X-ray structure of the 33-residue polypeptide corresponding to the leucine zipper of GCN4 was determined by Peter Kim and Thomas Alber^[1].

Binding

The Leucine Zipper

Binding with DNA

Function

See Also

2zta 1ysa

Reference

1. ↑ Voet, Donald; Voet, Judith G.; Pratt, Charlotte W. Fundamentals of Biochemistry: Life at the Molecular Level. 3rd Ed. Hoboken, NJ: Wiley, 2008.