1e6e
From Proteopedia
(New page: 200px<br /> <applet load="1e6e" size="450" color="white" frame="true" align="right" spinBox="true" caption="1e6e, resolution 2.3Å" /> '''ADRENODOXIN REDUCTAS...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1E6E is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]] with SO4, FAD and FES as [[http://en.wikipedia.org/wiki/ligands ligands]]. The following page contains interesting information on the relation of 1E6E with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb82_1.html Cytochrome p450]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.18.1.2 1.18.1.2]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1E6E OCA]]. | + | 1E6E is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]] with SO4, FAD and FES as [[http://en.wikipedia.org/wiki/ligands ligands]]. The following page contains interesting information on the relation of 1E6E with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb82_1.html Cytochrome p450]]. Active as [[http://en.wikipedia.org/wiki/Ferredoxin--NADP(+)_reductase Ferredoxin--NADP(+) reductase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.18.1.2 1.18.1.2]]. Structure known Active Sites: AC1, AC5, AC6 and AC9. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1E6E OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
[[Category: Cytochrome p450]] | [[Category: Cytochrome p450]] | ||
| + | [[Category: Ferredoxin--NADP(+) reductase]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Bourenkov, G.]] | [[Category: Bourenkov, G.]] | ||
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[[Category: oxidoreductase]] | [[Category: oxidoreductase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:39:26 2007'' |
Revision as of 10:34, 30 October 2007
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ADRENODOXIN REDUCTASE/ADRENODOXIN COMPLEX OF MITOCHONDRIAL P450 SYSTEMS
Overview
The steroid hydroxylating system of adrenal cortex mitochondria consists, of the membrane-attached NADPH-dependent adrenodoxin reductase (AR), the, soluble one-electron transport protein adrenodoxin (Adx), and a, membrane-integrated cytochrome P450 of the CYP11 family. In the 2.3-A, resolution crystal structure of the Adx.AR complex, 580 A(2) of partly, polar surface are buried. Main interaction sites are centered around, Asp(79), Asp(76), Asp(72), and Asp(39) of Adx and around Arg(211), Arg(240), Arg(244), and Lys(27) of AR, respectively. In particular, the, region around Asp(39) defines a new protein interaction site for Adx, similar to those found in plant and bacterial ferredoxins. Additional, contacts involve the electron transfer region between the redox centers of, AR and Adx and ... [(full description)]
About this Structure
1E6E is a [Protein complex] structure of sequences from [Bos taurus] with SO4, FAD and FES as [ligands]. The following page contains interesting information on the relation of 1E6E with [Cytochrome p450]. Active as [Ferredoxin--NADP(+) reductase], with EC number [1.18.1.2]. Structure known Active Sites: AC1, AC5, AC6 and AC9. Full crystallographic information is available from [OCA].
Reference
Adrenodoxin reductase-adrenodoxin complex structure suggests electron transfer path in steroid biosynthesis., Muller JJ, Lapko A, Bourenkov G, Ruckpaul K, Heinemann U, J Biol Chem. 2001 Jan 26;276(4):2786-9. Epub 2000 Oct 25. PMID:11053423[[Category: [2fe-2s]ferredoxin]]
Page seeded by OCA on Tue Oct 30 12:39:26 2007
