Plasminogen activator

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[[1tpk]] - hTPA kringle 2 domain<br />
[[1tpk]] - hTPA kringle 2 domain<br />
[[1tpm]], [[1tpn]] - hTPA fibrin-binding domain – NMR
[[1tpm]], [[1tpn]] - hTPA fibrin-binding domain – NMR
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==Urokinase-type plasminogen activator [[Urokinase]]==
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 07:18, 13 December 2011

Template:STRUCTURE 1a5h

Plasminogen activator (PLA) is a serine protease which converts plasminogen to plasmin. It includes Tissue PLA (TPA) which is involved in breakdown of blood clots and urokinase-type PLA Urokinase. TPA structure contains heavy and light chains (HC, LC). PLA is inhibited by PLA inhibitor 1 and 2.

Contents

3D structures of plasminogen activator

1a5i – PLA residues 213-477 + EGR-CMK – Vampire bat
1bqy – PLA – Pit viper

Tissue plasminogen activator

1a5h – hTPA HC+LC + benzamidine – human
1rtf - hTPA HC+LC
1tpg – hTPA F1-G - NMR
1bda – hTPA catalytic domain (mutant) + EGR-CMK
1pk2 – hTPA kringle 2 domain + 6-aminohexanoic acid – NMR
1tpk - hTPA kringle 2 domain
1tpm, 1tpn - hTPA fibrin-binding domain – NMR

Urokinase-type plasminogen activator Urokinase

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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