2ch7
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:2ch7.gif|left|200px]]<br /><applet load="2ch7" size=" | + | [[Image:2ch7.gif|left|200px]]<br /><applet load="2ch7" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2ch7, resolution 2.50Å" /> | caption="2ch7, resolution 2.50Å" /> | ||
'''CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF A BACTERIAL CHEMORECEPTOR FROM THERMOTOGA MARITIMA'''<br /> | '''CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF A BACTERIAL CHEMORECEPTOR FROM THERMOTOGA MARITIMA'''<br /> | ||
| Line 7: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2CH7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima] with PB as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Pb Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http:// | + | 2CH7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima] with <scene name='pdbligand=PB:'>PB</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Site: <scene name='pdbsite=AC1:Pb+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CH7 OCA]. |
==Reference== | ==Reference== | ||
| Line 23: | Line 23: | ||
[[Category: signal transduction]] | [[Category: signal transduction]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:35:16 2008'' |
Revision as of 08:35, 3 February 2008
|
CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF A BACTERIAL CHEMORECEPTOR FROM THERMOTOGA MARITIMA
Overview
In bacterial chemotaxis, an assembly of transmembrane receptors, the CheA, histidine kinase and the adaptor protein CheW processes environmental, stimuli to regulate motility. The structure of a Thermotoga maritima, receptor cytoplasmic domain defines CheA interaction regions and metal, ion-coordinating charge centers that undergo chemical modification to tune, receptor response. Dimeric CheA-CheW, defined by crystallography and, pulsed ESR, positions two CheWs to form a cleft that is lined with, residues important for receptor interactions and sized to clamp one, receptor dimer. CheW residues involved in kinase activation map to, interfaces that orient the CheW clamps. CheA regulatory domains associate, in crystals through conserved hydrophobic surfaces. Such CheA, self-contacts align the CheW receptor clamps for binding receptor tips., Linking layers of ternary complexes with close-packed receptors generates, a lattice with reasonable component ratios, cooperative interactions among, receptors and accessible sites for modification enzymes.
About this Structure
2CH7 is a Single protein structure of sequence from Thermotoga maritima with as ligand. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Reconstruction of the chemotaxis receptor-kinase assembly., Park SY, Borbat PP, Gonzalez-Bonet G, Bhatnagar J, Pollard AM, Freed JH, Bilwes AM, Crane BR, Nat Struct Mol Biol. 2006 May;13(5):400-7. Epub 2006 Apr 23. PMID:16622408
Page seeded by OCA on Sun Feb 3 10:35:16 2008
