2jgo
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
| - | 2JGO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=ACE:'>ACE</scene>, <scene name='pdbligand=NH2:'>NH2</scene> and <scene name='pdbligand=ARS:'>ARS</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Nh2 Binding Site For Chain C'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGO OCA]. | + | 2JGO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=ACE:'>ACE</scene>, <scene name='pdbligand=NH2:'>NH2</scene> and <scene name='pdbligand=ARS:'>ARS</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=AC1:Nh2+Binding+Site+For+Chain+C'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGO OCA]. |
==Reference== | ==Reference== | ||
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[[Category: three-stranded coiled coil]] | [[Category: three-stranded coiled coil]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:45:39 2008'' |
Revision as of 08:45, 3 February 2008
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STUCTURE OF THE ARSENATED DE NOVO DESIGNED PEPTIDE COIL SER L9C
Overview
Arsenic, a contaminant of water supplies worldwide, is one of the most, toxic inorganic ions. Despite arsenic's health impact, there is relatively, little structural detail known about its interactions with proteins., Bacteria such as Escherichia coli have evolved arsenic resistance using, the Ars operon that is regulated by ArsR, a repressor protein that, dissociates from DNA when As(III) binds. This protein undergoes a critical, conformational change upon binding As(III) with three cysteine residues., Unfortunately, structures of ArsR with or without As(III) have not been, reported. Alternatively, de novo designed peptides can bind As(III) in an, endo configuration within a thiolate-rich environment consistent with that, proposed for both ArsR and ArsD. We report the structure of the As(III), complex of Coil Ser L9C to a 1.8-A resolution, providing x-ray, characterization of As(III) in a Tris thiolate protein environment and, allowing a structural basis by which to understand arsenated ArsR.
About this Structure
2JGO is a Single protein structure of sequence from [1] with , , and as ligands. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
Identifying important structural characteristics of arsenic resistance proteins by using designed three-stranded coiled coils., Touw DS, Nordman CE, Stuckey JA, Pecoraro VL, Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):11969-74. Epub 2007 Jul 3. PMID:17609383
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