C-di-GMP
From Proteopedia
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| + | <applet load='2v0n' scene='C-di-GMP/C-di-gmp/1' size='400' frame='true' align='right' caption='cyclic di-GMP, as found in complex with the diguanylate cyclase PleD [[2v0n]]' /> | ||
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Cyclic di-GMP, (bis-(3'-5') cyclic diguanylic acid)<br><br> | Cyclic di-GMP, (bis-(3'-5') cyclic diguanylic acid)<br><br> | ||
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C-di-GMP is a second messenger that mediates the regulation of cell-surface associated traits in bacteria. | C-di-GMP is a second messenger that mediates the regulation of cell-surface associated traits in bacteria. | ||
| - | <scene name=' | + | <scene name='C-di-GMP/C-di-gmp/3'>C-di-GMP</scene> |
| - | is a cyclic dinucleotide with a 12-membered macro-cycle composed of the the phosphate and ribose moieties. It tends to associate to form <scene name='C-di-GMP/C-di-gmp/ | + | is a cyclic dinucleotide with a 12-membered macro-cycle composed of the the phosphate and ribose moieties. It tends to associate to form <scene name='C-di-GMP/C-di-gmp/4'>dimers</scene> with intercalated, stacked bases. |
| - | Several protein structures involved in c-di-GMP signaling have been determined ( | + | Several protein structures involved in c-di-GMP signaling have been determined (see [[C-di-GMP signaling]]). |
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[http://www.uniprot.org/keywords/973 UNIPROT link] | [http://www.uniprot.org/keywords/973 UNIPROT link] | ||
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<ref group="xtra">PMID:2158107</ref><ref group="xtra">PMID: 8286055 </ref> | <ref group="xtra">PMID:2158107</ref><ref group="xtra">PMID: 8286055 </ref> | ||
<references group="xtra"/> | <references group="xtra"/> | ||
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| + | [[Category: C-di-GMP]] | ||
Current revision
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Cyclic di-GMP, (bis-(3'-5') cyclic diguanylic acid)
C-di-GMP is a second messenger that mediates the regulation of cell-surface associated traits in bacteria.
is a cyclic dinucleotide with a 12-membered macro-cycle composed of the the phosphate and ribose moieties. It tends to associate to form with intercalated, stacked bases.
Several protein structures involved in c-di-GMP signaling have been determined (see C-di-GMP signaling).
References
Reviews:
- Egli M, Gessner RV, Williams LD, Quigley GJ, van der Marel GA, van Boom JH, Rich A, Frederick CA. Atomic-resolution structure of the cellulose synthase regulator cyclic diguanylic acid. Proc Natl Acad Sci U S A. 1990 Apr;87(8):3235-9. PMID:2158107
- Guan Y, Gao YG, Liaw YC, Robinson H, Wang AH. Molecular structure of cyclic diguanylic acid at 1 A resolution of two crystal forms: self-association, interactions with metal ion/planar dyes and modeling studies. J Biomol Struct Dyn. 1993 Oct;11(2):253-76. PMID:8286055
