1fpp
From Proteopedia
(New page: 200px<br /> <applet load="1fpp" size="450" color="white" frame="true" align="right" spinBox="true" caption="1fpp, resolution 2.75Å" /> '''PROTEIN FARNESYLTRA...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1FPP is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]] with ZN, PO4 and FPP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1FPP OCA]]. | + | 1FPP is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]] with ZN, PO4 and FPP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: ZN. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1FPP OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: zinc]] | [[Category: zinc]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:50:58 2007'' |
Revision as of 10:46, 30 October 2007
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PROTEIN FARNESYLTRANSFERASE COMPLEX WITH FARNESYL DIPHOSPHATE
Overview
The rat protein farnesyltransferase crystal structure has been solved by, multiple isomorphous replacement methods at a resolution of 2.75 A. The, three-dimensional structure, together with recent data on the effects of, several mutations, led us to propose a model for substrate binding which, differs from the model presented by Park et al. based on their independent, structure determination [Park, H. -W., Boduluri, S. R., Moomaw, J. F., Casey, P. J., and Beese, L. S. (1997) Science 275, 1800-1804]. Both, farnesyl diphosphate and peptide substrates can be accommodated in the, hydrophobic active-site barrel, with the sole charged residue inside the, barrel, Arg202 of the beta-subunit, forming a salt bridge with the, negatively charged carboxy terminus of peptide substrates. Our proposals, ... [(full description)]
About this Structure
1FPP is a [Protein complex] structure of sequences from [Rattus norvegicus] with ZN, PO4 and FPP as [ligands]. Structure known Active Site: ZN. Full crystallographic information is available from [OCA].
Reference
Protein farnesyltransferase: structure and implications for substrate binding., Dunten P, Kammlott U, Crowther R, Weber D, Palermo R, Birktoft J, Biochemistry. 1998 Jun 2;37(22):7907-12. PMID:9609683
Page seeded by OCA on Tue Oct 30 12:50:58 2007
Categories: Protein complex | Rattus norvegicus | Birktoft, J. | Crowther, R. | Dunten, P. | Kammlott, U. | Palermo, R. | Weber, D. | FPP | PO4 | ZN | Heterodimer | Membrane localization | Prenyltransferase | Zinc
