1ajv
From Proteopedia
(New page: 200px<br /> <applet load="1ajv" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ajv, resolution 2.00Å" /> '''HIV-1 PROTEASE IN C...) |
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caption="1ajv, resolution 2.00Å" /> | caption="1ajv, resolution 2.00Å" /> | ||
'''HIV-1 PROTEASE IN COMPLEX WITH THE CYCLIC SULFAMIDE INHIBITOR AHA006'''<br /> | '''HIV-1 PROTEASE IN COMPLEX WITH THE CYCLIC SULFAMIDE INHIBITOR AHA006'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1AJV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_1_(isolate_12) Human immunodeficiency virus type 1 (isolate 12)] with NMB as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] Full crystallographic information is available from [http:// | + | 1AJV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_1_(isolate_12) Human immunodeficiency virus type 1 (isolate 12)] with <scene name='pdbligand=NMB:'>NMB</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AJV OCA]. |
==Reference== | ==Reference== | ||
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[[Category: protease]] | [[Category: protease]] | ||
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Revision as of 13:29, 15 February 2008
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HIV-1 PROTEASE IN COMPLEX WITH THE CYCLIC SULFAMIDE INHIBITOR AHA006
Overview
Two cyclic, C2-symmetric HIV-1 protease inhibitors, one sulfamide and one, urea derivative, both comprising phenyl ether groups in the P1/P1', positions, were cocrystallized with HIV-1 protease, and the crystal, structures were determined to 2.0 A resolution. The structure of the urea, 2 showed a conformation similar to that reported for the related urea 3 by, Lam et al., while the sulfamide 1 adopted an unanticipated conformation in, which the P1' and P2' side chains were transposed.
About this Structure
1AJV is a Single protein structure of sequence from Human immunodeficiency virus type 1 (isolate 12) with as ligand. Active as HIV-1 retropepsin, with EC number 3.4.23.16 Full crystallographic information is available from OCA.
Reference
Unexpected binding mode of a cyclic sulfamide HIV-1 protease inhibitor., Backbro K, Lowgren S, Osterlund K, Atepo J, Unge T, Hulten J, Bonham NM, Schaal W, Karlen A, Hallberg A, J Med Chem. 1997 Mar 14;40(6):898-902. PMID:9083478
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