1c1e

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(New page: 200px<br /> <applet load="1c1e" size="450" color="white" frame="true" align="right" spinBox="true" caption="1c1e, resolution 1.9&Aring;" /> '''CRYSTAL STRUCTURE OF...)
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<applet load="1c1e" size="450" color="white" frame="true" align="right" spinBox="true"
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caption="1c1e, resolution 1.9&Aring;" />
caption="1c1e, resolution 1.9&Aring;" />
'''CRYSTAL STRUCTURE OF A DIELS-ALDERASE CATALYTIC ANTIBODY 1E9 IN COMPLEX WITH ITS HAPTEN'''<br />
'''CRYSTAL STRUCTURE OF A DIELS-ALDERASE CATALYTIC ANTIBODY 1E9 IN COMPLEX WITH ITS HAPTEN'''<br />
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==About this Structure==
==About this Structure==
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1C1E is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with ENH and DMR as [http://en.wikipedia.org/wiki/ligands ligands]. The following page contains interesting information on the relation of 1C1E with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb21_1.html Antibodies]]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1C1E OCA].
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1C1E is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=ENH:'>ENH</scene> and <scene name='pdbligand=DMR:'>DMR</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. The following page contains interesting information on the relation of 1C1E with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb21_1.html Antibodies]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1E OCA].
==Reference==
==Reference==
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[[Category: immunoglobulin]]
[[Category: immunoglobulin]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 18 08:57:57 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:34:04 2008''

Revision as of 13:34, 15 February 2008

Image:1c1e.jpg

1c1e, resolution 1.9Å

Drag the structure with the mouse to rotate

CRYSTAL STRUCTURE OF A DIELS-ALDERASE CATALYTIC ANTIBODY 1E9 IN COMPLEX WITH ITS HAPTEN

Overview

The crystal structure of an efficient Diels-Alder antibody catalyst at 1.9, angstrom resolution reveals almost perfect shape complementarity with its, transition state analog. Comparison with highly related progesterone and, Diels-Alderase antibodies that arose from the same primordial germ line, template shows the relatively subtle mutational steps that were able to, evolve both structural complementarity and catalytic efficiency.

About this Structure

1C1E is a Protein complex structure of sequences from Mus musculus with and as ligands. The following page contains interesting information on the relation of 1C1E with [Antibodies]. Full crystallographic information is available from OCA.

Reference

Evolution of shape complementarity and catalytic efficiency from a primordial antibody template., Xu J, Deng Q, Chen J, Houk KN, Bartek J, Hilvert D, Wilson IA, Science. 1999 Dec 17;286(5448):2345-8. PMID:10600746

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