1d4n
From Proteopedia
(New page: 200px<br /> <applet load="1d4n" size="450" color="white" frame="true" align="right" spinBox="true" caption="1d4n, resolution 2.00Å" /> '''HUMAN SERUM TRANSFE...) |
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| - | [[Image:1d4n. | + | [[Image:1d4n.jpg|left|200px]]<br /><applet load="1d4n" size="350" color="white" frame="true" align="right" spinBox="true" |
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caption="1d4n, resolution 2.00Å" /> | caption="1d4n, resolution 2.00Å" /> | ||
'''HUMAN SERUM TRANSFERRIN'''<br /> | '''HUMAN SERUM TRANSFERRIN'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1D4N is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CO3 and FE as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1D4N is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CO3:'>CO3</scene> and <scene name='pdbligand=FE:'>FE</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D4N OCA]. |
==Reference== | ==Reference== | ||
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[[Category: transferrin]] | [[Category: transferrin]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:38:26 2008'' |
Revision as of 13:38, 15 February 2008
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HUMAN SERUM TRANSFERRIN
Contents |
Overview
The X-ray crystallographic structures of two mutants (K206Q and H207E) of, the N-lobe of human transferrin (hTF/2N) have been determined to high, resolution (1.8 and 2.0 A, respectively). Both mutant proteins bind iron, with greater affinity than native hTF/2N. The structures of the K206Q and, H207E mutants show interactions (both H-bonding and electrostatic) that, stabilize the interaction of Lys296 in the closed conformation, thereby, stabilizing the iron bound forms.
Disease
Known diseases associated with this structure: Atransferrinemia OMIM:[190000], Iron deficiency anemia, susceptibility to OMIM:[190000]
About this Structure
1D4N is a Single protein structure of sequence from Homo sapiens with and as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structures of two mutants (K206Q, H207E) of the N-lobe of human transferrin with increased affinity for iron., Yang AH, MacGillivray RT, Chen J, Luo Y, Wang Y, Brayer GD, Mason AB, Woodworth RC, Murphy ME, Protein Sci. 2000 Jan;9(1):49-52. PMID:10739246
Page seeded by OCA on Fri Feb 15 15:38:26 2008
Categories: Homo sapiens | Single protein | Brayer, G.D. | Chen, J. | Luo, Y. | MacGillivray, R.T.A. | Mason, A. | Murphy, M.E.P. | Wang, Y. | Woodworth, R.C. | Yang, H.W. | CO3 | FE | Carbonate | Glycoprotein | Iron transport | Iron-release | N-lobe | Transferrin
