Journal:JMB:2
From Proteopedia
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<applet load="Workbench_test2.pdb" size="500" color="" frame="true" spin="on" Scene ='Journal:JMB:2/Opening/2' align="right" caption=" rePON1 with 2HQ ''"/> | <applet load="Workbench_test2.pdb" size="500" color="" frame="true" spin="on" Scene ='Journal:JMB:2/Opening/2' align="right" caption=" rePON1 with 2HQ ''"/> | ||
=== Catalytic versatility and backups in enzyme active sites: The case of serum paraoxanase 1 === | === Catalytic versatility and backups in enzyme active sites: The case of serum paraoxanase 1 === | ||
| - | <big>Moshe Ben-David, Mikael Elias, Jean-Jacques Filippi, Elisabet Dunach, Israel Silman, Joel Sussman and Dan Tawfik, PhD</big><ref > | + | <big>Moshe Ben-David, Mikael Elias, Jean-Jacques Filippi, Elisabet Dunach, Israel Silman, Joel Sussman and Dan Tawfik, PhD</big> <ref >doi 10.1016/j.jmb.2012.02.042</ref> |
<hr/> | <hr/> | ||
<b>Molecular Tour</b><br> | <b>Molecular Tour</b><br> | ||
Revision as of 07:20, 18 March 2012
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Catalytic versatility and backups in enzyme active sites: The case of serum paraoxanase 1
Moshe Ben-David, Mikael Elias, Jean-Jacques Filippi, Elisabet Dunach, Israel Silman, Joel Sussman and Dan Tawfik, PhD [1]
Molecular Tour
New 2HQ/rePON1 complex at pH 6.5 (active-site loop residues shown in ball-and-stick)
New rePON1 at pH 6.5
Old rePON1 at pH 4.5
Figure 2. Structural details of the 2HQ/rePON1 complex at pH 6.5; 2HQ and the structured active-site loop in the rePON1-2HQ complex structure. Overlay of the phosphate ion in the apo rePON1 at pH 6.5 and of 2HQ in the rePON1-2HQ complex. The first segment of the active-site loop, and residues Y71 and I74 in particular, comprises part of PON1's active-site wall. Interactions of 2HQ with active-site residues (interactions with the catalytic Ca2+ are highlighted in red).
- ↑ Ben-David M, Elias M, Filippi JJ, Dunach E, Silman I, Sussman JL, Tawfik DS. Catalytic Versatility and Backups in Enzyme Active Sites: The Case of Serum Paraoxonase 1. J Mol Biol. 2012 Mar 1. PMID:22387469 doi:10.1016/j.jmb.2012.02.042
