This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1hzm
From Proteopedia
(New page: 200px<br /> <applet load="1hzm" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hzm" /> '''STRUCTURE OF ERK2 BINDING DOMAIN OF MAPK PH...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1hzm. | + | [[Image:1hzm.jpg|left|200px]]<br /><applet load="1hzm" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1hzm" size=" | + | |
caption="1hzm" /> | caption="1hzm" /> | ||
'''STRUCTURE OF ERK2 BINDING DOMAIN OF MAPK PHOSPHATASE MKP-3: STRUCTURAL INSIGHTS INTO MKP-3 ACTIVATION BY ERK2'''<br /> | '''STRUCTURE OF ERK2 BINDING DOMAIN OF MAPK PHOSPHATASE MKP-3: STRUCTURAL INSIGHTS INTO MKP-3 ACTIVATION BY ERK2'''<br /> | ||
| Line 8: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1HZM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1HZM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HZM OCA]. |
==Reference== | ==Reference== | ||
| Line 18: | Line 17: | ||
[[Category: hydrolase]] | [[Category: hydrolase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:58:54 2008'' |
Revision as of 13:58, 15 February 2008
|
STRUCTURE OF ERK2 BINDING DOMAIN OF MAPK PHOSPHATASE MKP-3: STRUCTURAL INSIGHTS INTO MKP-3 ACTIVATION BY ERK2
Overview
MAP kinases (MAPKs), which control mitogenic signal transduction in all, eukaryotic organisms, are inactivated by dual specificity MAPK, phosphatases (MKPs). MKP-3, a prototypical MKP, achieves substrate, specificity through its N-terminal domain binding to the MAPK ERK2, resulting in the activation of its C-terminal phosphatase domain. The, solution structure and biochemical analysis of the ERK2 binding (EB), domain of MKP-3 show that regions that are essential for ERK2 binding, partly overlap with its sites that interact with the C-terminal catalytic, domain, and that these interactions are functionally coupled to the active, site residues of MKP-3. Our findings suggest a novel mechanism by which, the EB domain binding to ERK2 is transduced to cause a conformational, change of the C-terminal catalytic domain, resulting in the enzymatic, activation of MKP-3.
About this Structure
1HZM is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Solution structure of ERK2 binding domain of MAPK phosphatase MKP-3: structural insights into MKP-3 activation by ERK2., Farooq A, Chaturvedi G, Mujtaba S, Plotnikova O, Zeng L, Dhalluin C, Ashton R, Zhou MM, Mol Cell. 2001 Feb;7(2):387-99. PMID:11239467
Page seeded by OCA on Fri Feb 15 15:58:54 2008
