1ik0
From Proteopedia
(New page: 200px<br /> <applet load="1ik0" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ik0" /> '''Solution Structure of Human IL-13'''<br /> ...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1ik0. | + | [[Image:1ik0.jpg|left|200px]]<br /><applet load="1ik0" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1ik0" size=" | + | |
caption="1ik0" /> | caption="1ik0" /> | ||
'''Solution Structure of Human IL-13'''<br /> | '''Solution Structure of Human IL-13'''<br /> | ||
| Line 11: | Line 10: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1IK0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1IK0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IK0 OCA]. |
==Reference== | ==Reference== | ||
| Line 23: | Line 22: | ||
[[Category: left-handed four-helix bundle]] | [[Category: left-handed four-helix bundle]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:01:55 2008'' |
Revision as of 14:01, 15 February 2008
|
Solution Structure of Human IL-13
Contents |
Overview
Interleukin-13 has been implicated as a key factor in asthma, allergy, atopy and inflammatory response, establishing the protein as a valuable, therapeutic target. The high-resolution solution structure of human IL-13, has been determined by multidimensional NMR. The resulting structure is, consistent with previous short-chain left-handed four-helix bundles, where, a significant similarity in the folding topology between IL-13 and IL-4, was observed. IL-13 shares a significant overlap in biological function, with IL-4, a result of the common alpha chain component (IL-4Ralpha) in, their respective receptors. Based on the available structural and, mutational data, an IL-13/IL-4Ralpha model and a sequential mechanism for, forming the signaling heterodimer is proposed for IL-13.
Disease
Known diseases associated with this structure: Allergic rhinitis, susceptibility to OMIM:[147683], Asthma, susceptibility to OMIM:[147683]
About this Structure
1IK0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Solution structure of human IL-13 and implication for receptor binding., Moy FJ, Diblasio E, Wilhelm J, Powers R, J Mol Biol. 2001 Jun 29;310(1):219-30. PMID:11419948
Page seeded by OCA on Fri Feb 15 16:01:55 2008
