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1inr
From Proteopedia
(New page: 200px<br /> <applet load="1inr" size="450" color="white" frame="true" align="right" spinBox="true" caption="1inr, resolution 2.Å" /> '''CYTOKINE SYNTHESIS'''...) |
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caption="1inr, resolution 2.Å" /> | caption="1inr, resolution 2.Å" /> | ||
'''CYTOKINE SYNTHESIS'''<br /> | '''CYTOKINE SYNTHESIS'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1INR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1INR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1INR OCA]. |
==Reference== | ==Reference== | ||
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[[Category: cytokine]] | [[Category: cytokine]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:02:39 2008'' |
Revision as of 14:02, 15 February 2008
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CYTOKINE SYNTHESIS
Contents |
Overview
The crystal structure of recombinant human interleukin 10 (rhIL-10) has, been determined by X-ray crystallography at 2.0 A resolution. Interleukin, 10 is a dimer composed of identical polypeptide chains related by a 2-fold, axis. The molecule is predominantly alpha-helical. The main-chain fold, resembles that of interferon gamma (IFN-gamma) in which the structural, integrity of each domain is dependent on the intertwining of helices from, each peptide chain. Comparison of rhIL-10 and IFN-gamma reveals, differences in helix lengths and orientations of the 2-fold related, domains. Interleukin 10 and IFN-gamma contain several conserved residues, in their internal cores which suggest a possible "fingerprint" for, detection of other members of this fold.
Disease
Known diseases associated with this structure: Graft-versus-host disease, protection against OMIM:[124092], HIV-1, susceptibility to OMIM:[124092], Rheumatoid arthritis, progression of OMIM:[124092]
About this Structure
1INR is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of interleukin 10 reveals an interferon gamma-like fold., Walter MR, Nagabhushan TL, Biochemistry. 1995 Sep 26;34(38):12118-25. PMID:7547951
Page seeded by OCA on Fri Feb 15 16:02:39 2008
