1j2f
From Proteopedia
(New page: 200px<br /> <applet load="1j2f" size="450" color="white" frame="true" align="right" spinBox="true" caption="1j2f, resolution 2.3Å" /> '''X-ray crystal struct...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1j2f. | + | [[Image:1j2f.jpg|left|200px]]<br /><applet load="1j2f" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1j2f" size=" | + | |
caption="1j2f, resolution 2.3Å" /> | caption="1j2f, resolution 2.3Å" /> | ||
'''X-ray crystal structure of IRF-3 and its functional implications'''<br /> | '''X-ray crystal structure of IRF-3 and its functional implications'''<br /> | ||
| Line 8: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1J2F is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1J2F is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J2F OCA]. |
==Reference== | ==Reference== | ||
| Line 25: | Line 24: | ||
[[Category: transcription factor]] | [[Category: transcription factor]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:04:55 2008'' |
Revision as of 14:04, 15 February 2008
|
X-ray crystal structure of IRF-3 and its functional implications
Overview
Transcription factor IRF-3 is post-translationally activated by Toll-like, receptor (TLR) signaling and has critical roles in the regulation of, innate immunity. Here we present the X-ray crystal structure of the, C-terminal regulatory domain of IRF-3(175-427) (IRF-3 175C) at a, resolution of 2.3 A. IRF-3 175C is structurally similar to the Mad, homology domain 2 of the Smad family. Structural and functional analyses, reveal phosphorylation-induced IRF-3 dimerization, which generates an, extensive acidic pocket responsible for binding with p300/CBP. Although, TLR and Smad signaling are evolutionarily independent, our results suggest, that IRF-3 originates from Smad and acquires its function downstream of, TLR.
About this Structure
1J2F is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
X-ray crystal structure of IRF-3 and its functional implications., Takahasi K, Suzuki NN, Horiuchi M, Mori M, Suhara W, Okabe Y, Fukuhara Y, Terasawa H, Akira S, Fujita T, Inagaki F, Nat Struct Biol. 2003 Nov;10(11):922-7. Epub 2003 Oct 12. PMID:14555995
Page seeded by OCA on Fri Feb 15 16:04:55 2008
