Nitroreductase
From Proteopedia
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[[3h4o]], [[3koq]] - NR – ''Clostridium difficile''<br /> | [[3h4o]], [[3koq]] - NR – ''Clostridium difficile''<br /> | ||
[[3gr3]] – NR – ''Bartonella henselae''<br /> | [[3gr3]] – NR – ''Bartonella henselae''<br /> | ||
| - | [[3hzn]] – NR – ''Salmonella typhimurium | + | [[3hzn]] – NR – ''Salmonella typhimurium''<br /> |
[[3k6h]] – NR – ''Agrobacterium tumefaciens''<br /> | [[3k6h]] – NR – ''Agrobacterium tumefaciens''<br /> | ||
[[2wqf]] – NR – ''Lactococcus lactis''<br /> | [[2wqf]] – NR – ''Lactococcus lactis''<br /> | ||
Revision as of 10:30, 8 April 2012
Nitroreductase (NR) is involved in the reduction of nitrogen-containing compounds including those containing NO2 group. The NO2 group is reduced to hydroxylamine. NR use FMN as cofactor. Among NRs are the oxygen-insensitive NAD(P)H NR and NADH dehydrogenase. The NR is of special interest due to its potential use as activator of prodrugs in cancer therapy.
3D structures of nitroreductase
1f5v , 1oo5 – EcNR – Escherichia coli
3bm1, 1ds7 – EcNR minimal
3bm2 – EcNR minimal -FMN
1nec, 1kqd – EclNR – Enterobacter cloacae
1ywq, 2i7h – NR – Bacillus cereus
2b67 – NR – Streptococcus pneumonia
3ek3, 3hoi – NR – Bacterioides fragilis
3g14 – NR – Clostridium novyi
3h4o, 3koq - NR – Clostridium difficile
3gr3 – NR – Bartonella henselae
3hzn – NR – Salmonella typhimurium
3k6h – NR – Agrobacterium tumefaciens
2wqf – NR – Lactococcus lactis
2wzv – MsNR – Mycobacterium smegmatis
3of4 – NR FMN/FAD – Idiomarina loihiensis
3n2s – NR – Bacillus subtilis
3pxv – NR – Desulfitobacterium hafniense
3qdl – NR – Helicobacter pylori
3r5l, 3r5p - MtNR – Mycobacterium tuberculosis
3r5r, 3r5w – MtNR F420
Nitroreductase binary complex
1kqb – EclNR + benzoate
1kqc – EclNR + acetate
1ylr, 1ylu - EcNR + acetate
1icr, 1icu, 1icv – EcNR + nicotinic acid
1ooq – EcNR + dicoumarol
1oo6, 1oon, 1idt – EcNR + benzamide derivative
1yki – EcNR + antibiotic
2wzw - MsNR + NADPH
