Pyruvate-ferredoxin oxidoreductase

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	[[2c3u]] - DaPFOR + pyruvate + TDP derivative<br />		[[2c3u]] - DaPFOR + pyruvate + TDP derivative<br />
	[[2raa]] - PFOR γ subunit - ''Thermotoga maritima''		[[2raa]] - PFOR γ subunit - ''Thermotoga maritima''
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Revision as of 11:14, 17 April 2012

spinqualitylabelsall models Pyruvate-ferredoxin oxidoredoxin with Fe4S4 cluster complex with thiamin diphosphate and pyruvate 2c3o Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Pyruvate-ferredoxin oxidoreductase (PFOR) is an enzyme of the fermentation cycle which catalyzes the oxidative decarboxylation of pyruvate to acetyl CoA and CO2. This reaction provides the electron source for the reduction of ferredoxin. The reaction is CoA-dependent and contains thiamine diphosphate (TDP). PFOR contains iron-sulfur clusters (Fe4S4).

3D structures of pyruvate-ferredoxin oxidoreductase

1b0p, 2c3m – DaPFOR + TDP – Desulfovibrio africanus
2pda, 2c3o, 2c42 - DaPFOR + pyruvate + TDP
1kek, 2c3y - DaPFOR + CO2 + acetyl-TDP
2c3p - DaPFOR + TDP derivative
2c3u - DaPFOR + pyruvate + TDP derivative
2raa - PFOR γ subunit - Thermotoga maritima