1lw3
From Proteopedia
(New page: 200px<br /> <applet load="1lw3" size="450" color="white" frame="true" align="right" spinBox="true" caption="1lw3, resolution 2.3Å" /> '''Crystal Structure of...) |
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caption="1lw3, resolution 2.3Å" /> | caption="1lw3, resolution 2.3Å" /> | ||
'''Crystal Structure of Myotubularin-related protein 2 complexed with phosphate'''<br /> | '''Crystal Structure of Myotubularin-related protein 2 complexed with phosphate'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1LW3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with PO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Phosphatidylinositol-3-phosphatase Phosphatidylinositol-3-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.64 3.1.3.64] Full crystallographic information is available from [http:// | + | 1LW3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=PO4:'>PO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Phosphatidylinositol-3-phosphatase Phosphatidylinositol-3-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.64 3.1.3.64] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LW3 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: protein-phosphate complex]] | [[Category: protein-phosphate complex]] | ||
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Revision as of 14:20, 15 February 2008
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Crystal Structure of Myotubularin-related protein 2 complexed with phosphate
Contents |
Overview
Myotubularin-related proteins are a large subfamily of protein tyrosine, phosphatases (PTPs) that dephosphorylate D3-phosphorylated inositol, lipids. Mutations in members of the myotubularin family cause the human, neuromuscular disorders myotubular myopathy and type 4B, Charcot-Marie-Tooth syndrome. The crystal structure of a representative, member of this family, MTMR2, reveals a phosphatase domain that is, structurally unique among PTPs. A series of mutants are described that, exhibit altered enzymatic activity and provide insight into the, specificity of myotubularin phosphatases toward phosphoinositide, substrates. The structure also reveals that the GRAM domain, found in, myotubularin family phosphatases and predicted to occur in approximately, 180 proteins, is part of a larger motif with a pleckstrin homology (PH), domain fold. Finally, the MTMR2 structure will serve as a model for other, members of the myotubularin family and provide a framework for, understanding the mechanism whereby mutations in these proteins lead to, disease.
Disease
Known disease associated with this structure: Charcot-Marie-Tooth disease, type 4B1 OMIM:[603557]
About this Structure
1LW3 is a Single protein structure of sequence from Homo sapiens with as ligand. Active as Phosphatidylinositol-3-phosphatase, with EC number 3.1.3.64 Full crystallographic information is available from OCA.
Reference
Crystal structure of a phosphoinositide phosphatase, MTMR2: insights into myotubular myopathy and Charcot-Marie-Tooth syndrome., Begley MJ, Taylor GS, Kim SA, Veine DM, Dixon JE, Stuckey JA, Mol Cell. 2003 Dec;12(6):1391-402. PMID:14690594
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