1n4x
From Proteopedia
(New page: 200px<br /> <applet load="1n4x" size="450" color="white" frame="true" align="right" spinBox="true" caption="1n4x, resolution 1.7Å" /> '''Structure of scFv 16...) |
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caption="1n4x, resolution 1.7Å" /> | caption="1n4x, resolution 1.7Å" /> | ||
'''Structure of scFv 1696 at acidic pH'''<br /> | '''Structure of scFv 1696 at acidic pH'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1N4X is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with CL as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1N4X is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=CL:'>CL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4X OCA]. |
==Reference== | ==Reference== | ||
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[[Category: immunoglobulin]] | [[Category: immunoglobulin]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:27:00 2008'' |
Revision as of 14:27, 15 February 2008
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Structure of scFv 1696 at acidic pH
Overview
The monoclonal antibody 1696, which was raised against the HIV-1 protease, inhibits the catalytic activity of the enzyme from both the HIV-1 and, HIV-2 strains. The antibody cross-reacts with peptides containing the, N-terminus of the enzyme, which is highly conserved between these strains., The crystal structure of a single-chain Fv fragment of 1696 (scFv-1696) in, the non-complexed form, solved at 1.7 A resolution, is compared with the, previously reported non-complexed Fab-1696 and antigen-bound scFv-1696, structures. Large conformational changes in the third hypervariable region, of the heavy chain and differences in relative orientation of the variable, domains are observed between the different structures.
About this Structure
1N4X is a Protein complex structure of sequences from Mus musculus with as ligand. Full crystallographic information is available from OCA.
Reference
Structure of a single-chain Fv fragment of an antibody that inhibits the HIV-1 and HIV-2 proteases., Lescar J, Brynda J, Fabry M, Horejsi M, Rezacova P, Sedlacek J, Bentley GA, Acta Crystallogr D Biol Crystallogr. 2003 May;59(Pt 5):955-7. Epub 2003, Apr 25. PMID:12777823
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