1os2
From Proteopedia
(New page: 200px<br /> <applet load="1os2" size="450" color="white" frame="true" align="right" spinBox="true" caption="1os2, resolution 2.15Å" /> '''Ternary enzyme-prod...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1os2. | + | [[Image:1os2.jpg|left|200px]]<br /><applet load="1os2" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1os2" size=" | + | |
caption="1os2, resolution 2.15Å" /> | caption="1os2, resolution 2.15Å" /> | ||
'''Ternary enzyme-product-inhibitor complexes of human MMP12'''<br /> | '''Ternary enzyme-product-inhibitor complexes of human MMP12'''<br /> | ||
==Disease== | ==Disease== | ||
| - | Known diseases associated with this structure: Cardiomyopathy, dilated, 1G OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188840 188840]], Cardiomyopathy, familial hypertrophic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188840 188840]], Muscular dystrophy, limb-girdle, type 2J OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188840 188840]], Myopathy, proximal, with early respiratory muscle involvement OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188840 188840]], Tibial muscular dystrophy, tardive OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188840 188840]] | + | Known diseases associated with this structure: Cardiomyopathy, dilated, 1G OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188840 188840]], Cardiomyopathy, familial hypertrophic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188840 188840]], Muscular dystrophy, limb-girdle, type 2J OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188840 188840]], Myopathy, early-onset, with fatal cardiomyopathy OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188840 188840]], Myopathy, proximal, with early respiratory muscle involvement OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188840 188840]], Tibial muscular dystrophy, tardive OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188840 188840]] |
==About this Structure== | ==About this Structure== | ||
| - | 1OS2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN, CA, ACT, AZI and HAE as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Macrophage_elastase Macrophage elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.65 3.4.24.65] Full crystallographic information is available from [http:// | + | 1OS2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=ACT:'>ACT</scene>, <scene name='pdbligand=AZI:'>AZI</scene> and <scene name='pdbligand=HAE:'>HAE</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Macrophage_elastase Macrophage elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.65 3.4.24.65] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OS2 OCA]. |
==Reference== | ==Reference== | ||
| Line 33: | Line 32: | ||
[[Category: mmp12]] | [[Category: mmp12]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:35:24 2008'' |
Revision as of 14:35, 15 February 2008
|
Ternary enzyme-product-inhibitor complexes of human MMP12
Disease
Known diseases associated with this structure: Cardiomyopathy, dilated, 1G OMIM:[188840], Cardiomyopathy, familial hypertrophic OMIM:[188840], Muscular dystrophy, limb-girdle, type 2J OMIM:[188840], Myopathy, early-onset, with fatal cardiomyopathy OMIM:[188840], Myopathy, proximal, with early respiratory muscle involvement OMIM:[188840], Tibial muscular dystrophy, tardive OMIM:[188840]
About this Structure
1OS2 is a Single protein structure of sequence from Homo sapiens with , , , and as ligands. Active as Macrophage elastase, with EC number 3.4.24.65 Full crystallographic information is available from OCA.
Reference
X-ray structures of binary and ternary enzyme-product-inhibitor complexes of matrix metalloproteinases., Bertini I, Calderone V, Fragai M, Luchinat C, Mangani S, Terni B, Angew Chem Int Ed Engl. 2003 Jun 16;42(23):2673-6. PMID:12813751
Page seeded by OCA on Fri Feb 15 16:35:24 2008
Categories: Homo sapiens | Macrophage elastase | Single protein | Bertini, I. | Calderone, V. | Fragai, M. | Luchinat, C. | Mangani, S. | Terni, B. | ACT | AZI | CA | HAE | ZN | Complex (elastase/inhibitor) | Elastase | Hydroxamic acid | Matrix metalloproteinase | Metallo elastase | Mmp12
