1oz3
From Proteopedia
(New page: 200px<br /> <applet load="1oz3" size="450" color="white" frame="true" align="right" spinBox="true" caption="1oz3, resolution 1.85Å" /> '''Crystal Structure o...) |
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| - | [[Image:1oz3. | + | [[Image:1oz3.jpg|left|200px]]<br /><applet load="1oz3" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1oz3" size=" | + | |
caption="1oz3, resolution 1.85Å" /> | caption="1oz3, resolution 1.85Å" /> | ||
'''Crystal Structure of 3-MBT repeats of lethal (3) malignant Brain Tumor (Native-I) at 1.85 angstrom'''<br /> | '''Crystal Structure of 3-MBT repeats of lethal (3) malignant Brain Tumor (Native-I) at 1.85 angstrom'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1OZ3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 and MES as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1OZ3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=MES:'>MES</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OZ3 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: three malignant brain tumor]] | [[Category: three malignant brain tumor]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:37:44 2008'' |
Revision as of 14:37, 15 February 2008
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Crystal Structure of 3-MBT repeats of lethal (3) malignant Brain Tumor (Native-I) at 1.85 angstrom
Overview
We report on the X-ray structure of three 100-amino acid mbt repeats in, h-l(3)mbt, a polycomb group protein involved in transcriptional, repression, whose gene is located in a region of chromosome 20 associated, with hematopoietic malignancies. Interdigitation between the extended arms, and cores of the mbt repeats results in a three-leaved propeller-like, architecture, containing a central cavity. We have identified one ligand, binding pocket per mbt repeat, which accommodates either the morphilino, ring of MES or the proline ring of the C-terminal peptide segment, within, a cavity lined by aromatic amino acids. Strikingly, phenotypic alterations, resulting from point mutations or deletions in the mbt repeats of the, related Drosophila SCM protein are clustered in and around the ligand, binding pocket.
About this Structure
1OZ3 is a Single protein structure of sequence from Homo sapiens with and as ligands. Full crystallographic information is available from OCA.
Reference
Malignant brain tumor repeats: a three-leaved propeller architecture with ligand/peptide binding pockets., Wang WK, Tereshko V, Boccuni P, MacGrogan D, Nimer SD, Patel DJ, Structure. 2003 Jul;11(7):775-89. PMID:12842041
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