1qz2

From Proteopedia

Revision as of 14:46, 15 February 2008

Crystal Structure of FKBP52 C-terminal Domain complex with the C-terminal peptide MEEVD of Hsp90

Overview

FK506-binding protein 52 (FKBP52), which binds FK506 and possesses, peptidylprolyl isomerase activity, is an important immunophilin involved, in the heterocomplex of steroid receptors with heat-shock protein 90. Here, we report the crystal structures of two overlapped fragments [N(1-260) and, C(145-459)] of FKBP52 and the complex with a C-terminal pentapeptide from, heat-shock protein 90. Based on the structures of these two overlapped, fragments, the complete putative structure of FKBP52 can be defined. The, structure of FKBP52 is composed of two consecutive FKBP domains, a, tetratricopeptide repeat domain and a short helical domain beyond the, final tetratricopeptide repeat motif. Key structural differences between, FKBP52 and FKBP51, including the relative orientations of the four domains, and some important residue substitutions, could account for the, differential functions of FKBPs.

About this Structure

1QZ2 is a Protein complex structure of sequences from Homo sapiens. Active as Peptidylprolyl isomerase, with EC number 5.2.1.8 Full crystallographic information is available from OCA.

Reference

3D structure of human FK506-binding protein 52: implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex., Wu B, Li P, Liu Y, Lou Z, Ding Y, Shu C, Ye S, Bartlam M, Shen B, Rao Z, Proc Natl Acad Sci U S A. 2004 Jun 1;101(22):8348-53. Epub 2004 May 24. PMID:15159550

Page seeded by OCA on Fri Feb 15 16:46:31 2008