1ukl
From Proteopedia
(New page: 200px<br /> <applet load="1ukl" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ukl, resolution 3.00Å" /> '''Crystal structure o...) |
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caption="1ukl, resolution 3.00Å" /> | caption="1ukl, resolution 3.00Å" /> | ||
'''Crystal structure of Importin-beta and SREBP-2 complex'''<br /> | '''Crystal structure of Importin-beta and SREBP-2 complex'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1UKL is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http:// | + | 1UKL is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UKL OCA]. |
==Reference== | ==Reference== | ||
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[[Category: transcription factor]] | [[Category: transcription factor]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:02:59 2008'' |
Revision as of 15:02, 15 February 2008
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Crystal structure of Importin-beta and SREBP-2 complex
Overview
The sterol regulatory element-binding protein 2 (SREBP-2), a nuclear, transcription factor that is essential for cholesterol metabolism, enters, the nucleus through a direct interaction of its helix-loop-helix leucine, zipper domain with importin-beta. We show the crystal structure of, importin-beta complexed with the active form of SREBP-2. Importin-beta, uses characteristic long helices like a pair of chopsticks to interact, with an SREBP-2 dimer. Importin-beta changes its conformation to reveal a, pseudo-twofold symmetry on its surface structure so that it can, accommodate a symmetric dimer molecule. Importin-beta may use a similar, strategy to recognize other dimeric cargoes.
About this Structure
1UKL is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.
Reference
The structure of importin-beta bound to SREBP-2: nuclear import of a transcription factor., Lee SJ, Sekimoto T, Yamashita E, Nagoshi E, Nakagawa A, Imamoto N, Yoshimura M, Sakai H, Chong KT, Tsukihara T, Yoneda Y, Science. 2003 Nov 28;302(5650):1571-5. PMID:14645851
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