1gnu
From Proteopedia
(New page: 200px<br /> <applet load="1gnu" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gnu, resolution 1.75Å" /> '''GABA(A) RECEPTOR AS...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1GNU is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with NI as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GNU OCA]]. | + | 1GNU is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with NI as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: NI. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GNU OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: ubiquitin-like]] | [[Category: ubiquitin-like]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:23:29 2007'' |
Revision as of 11:18, 30 October 2007
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GABA(A) RECEPTOR ASSOCIATED PROTEIN GABARAP
Overview
The gamma-aminobutyric acid receptor type A (GABA(A)) receptor-associated, protein (GABARAP) has been reported to mediate the interaction between the, GABA(A) receptor and microtubules. We present the three-dimensional, structure of GABARAP obtained by x-ray diffraction at 1.75 A resolution., The structure was determined by molecular replacement using the structure, of the homologous protein GATE-16. NMR spectroscopy of isotope-labeled, GABARAP showed the structure in solution to be compatible with the overall, fold but showed evidence of conformation heterogeneity that is not, apparent in the crystal structure. We assessed the binding of GABARAP to, peptides derived from reported binding partner proteins, including the, M3-M4 loop of the gamma2 subunit of the GABA(A) receptor and the ... [(full description)]
About this Structure
1GNU is a [Single protein] structure of sequence from [Homo sapiens] with NI as [ligand]. Structure known Active Site: NI. Full crystallographic information is available from [OCA].
Reference
The X-ray crystal structure and putative ligand-derived peptide binding properties of gamma-aminobutyric acid receptor type A receptor-associated protein., Knight D, Harris R, McAlister MS, Phelan JP, Geddes S, Moss SJ, Driscoll PC, Keep NH, J Biol Chem. 2002 Feb 15;277(7):5556-61. Epub 2001 Nov 29. PMID:11729197
Page seeded by OCA on Tue Oct 30 13:23:29 2007
Categories: Homo sapiens | Single protein | Driscoll, P.C. | Harris, R. | Keep, N.H. | Knight, D. | Moss, S. | NI | Receptor | Transport | Ubiquitin-like
