This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1uqu
From Proteopedia
(New page: 200px<br /> <applet load="1uqu" size="450" color="white" frame="true" align="right" spinBox="true" caption="1uqu, resolution 2.00Å" /> '''TREHALOSE-6-PHOSPHA...) |
|||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1UQU is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]] with UPG as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.15 2.4.1.15]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UQU OCA]]. | + | 1UQU is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]] with UPG as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Alpha,alpha-trehalose-phosphate_synthase_(UDP-forming) Alpha,alpha-trehalose-phosphate synthase (UDP-forming)]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.15 2.4.1.15]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UQU OCA]]. |
==Reference== | ==Reference== | ||
The donor subsite of trehalose-6-phosphate synthase: binary complexes with UDP-glucose and UDP-2-deoxy-2-fluoro-glucose at 2 A resolution., Gibson RP, Tarling CA, Roberts S, Withers SG, Davies GJ, J Biol Chem. 2004 Jan 16;279(3):1950-5. Epub 2003 Oct 21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14570926 14570926] | The donor subsite of trehalose-6-phosphate synthase: binary complexes with UDP-glucose and UDP-2-deoxy-2-fluoro-glucose at 2 A resolution., Gibson RP, Tarling CA, Roberts S, Withers SG, Davies GJ, J Biol Chem. 2004 Jan 16;279(3):1950-5. Epub 2003 Oct 21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14570926 14570926] | ||
| + | [[Category: Alpha,alpha-trehalose-phosphate synthase (UDP-forming)]] | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| Line 24: | Line 25: | ||
[[Category: transferase]] | [[Category: transferase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:26:58 2007'' |
Revision as of 11:22, 30 October 2007
|
TREHALOSE-6-PHOSPHATE FROM E. COLI BOUND WITH UDP-GLUCOSE.
Overview
Trehalose is an unusual non-reducing disaccharide that plays a variety of, biological roles, from food storage to cellular protection from, environmental stresses such as desiccation, pressure, heat-shock, extreme, cold, and oxygen radicals. It is also an integral component of the, cell-wall glycolipids of mycobacteria. The primary enzymatic route to, trehalose first involves the transfer of glucose from a UDP-glucose donor, to glucose-6-phosphate to form alpha,alpha-1,1 trehalose-6-phosphate. This, reaction, in which the configurations of two glycosidic bonds are set, simultaneously, is catalyzed by the glycosyltransferase, trehalose-6-phosphate synthase (OtsA), which acts with retention of the, anomeric configuration of the UDP-sugar donor. The classification of, activated ... [(full description)]
About this Structure
1UQU is a [Single protein] structure of sequence from [Escherichia coli] with UPG as [ligand]. Active as [Alpha,alpha-trehalose-phosphate synthase (UDP-forming)], with EC number [2.4.1.15]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
The donor subsite of trehalose-6-phosphate synthase: binary complexes with UDP-glucose and UDP-2-deoxy-2-fluoro-glucose at 2 A resolution., Gibson RP, Tarling CA, Roberts S, Withers SG, Davies GJ, J Biol Chem. 2004 Jan 16;279(3):1950-5. Epub 2003 Oct 21. PMID:14570926
Page seeded by OCA on Tue Oct 30 13:26:58 2007
