This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


Thermolysin

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 8: Line 8:
== 3D Structures of Thermolysin ==
== 3D Structures of Thermolysin ==
-
''Update December 2011''
+
''Update July 2012''
-
 
+
=== Thermolysin ===
=== Thermolysin ===
- 
[[2whz]], [[3fvp]], [[3dnz]], [[3do0]], [[3do1]], [[3do2]], [[2g4z]], [[2a7g]], [[1gxw]], [[1kei]], [[1l3f]], [[1tlx]], [[2tlx]], [[8tln]], [[3p7p]], [[3p7q]], [[3p7r]], [[3p7s]], [[3p7t]], [[3p7u]], [[3p7v]], [[3p7w]] – TML<br />
[[2whz]], [[3fvp]], [[3dnz]], [[3do0]], [[3do1]], [[3do2]], [[2g4z]], [[2a7g]], [[1gxw]], [[1kei]], [[1l3f]], [[1tlx]], [[2tlx]], [[8tln]], [[3p7p]], [[3p7q]], [[3p7r]], [[3p7s]], [[3p7t]], [[3p7u]], [[3p7v]], [[3p7w]] – TML<br />
Line 18: Line 16:
[[1trl]] - TML residues 255-316 – NMR<br />
[[1trl]] - TML residues 255-316 – NMR<br />
[[3fxs]], [[3fbo]], [[3eim]], [[1lna]], [[1lnb]], [[1lnc]], [[1lnd]], [[1lne]], [[1lnf]] - TML residues 233-548+metal ion replacing Ca<br />
[[3fxs]], [[3fbo]], [[3eim]], [[1lna]], [[1lnb]], [[1lnc]], [[1lnd]], [[1lne]], [[1lnf]] - TML residues 233-548+metal ion replacing Ca<br />
- 
=== TML+transition state analog ===
=== TML+transition state analog ===
- 
[[1tlp]], [[1tmn]], [[2tmn]], [[4tmn]], [[5tmn]] – TML+transition state analog<br />
[[1tlp]], [[1tmn]], [[2tmn]], [[4tmn]], [[5tmn]] – TML+transition state analog<br />
Line 27: Line 23:
===TML+ amino acid===
===TML+ amino acid===
-
[[1kl6]] – TML+ alanine
+
[[1kl6]] – TML+ alanine<br />
 +
[[3qgo]] – TML + phenylalanine methyl ester<br />
 +
[[3qh1]] – TML + benzyloxycarboxyl- aspartate<br />
 +
[[3qh5]] – TML + benzyloxycarboxyl- aspartate + phenylalanine methyl ester
=== TML+ dipeptide ===
=== TML+ dipeptide ===
- 
[[2wi0]], [[3tmn]] – TML+ dipeptide <br />
[[2wi0]], [[3tmn]] – TML+ dipeptide <br />
[[3fgd]] - TML residues 233-548+dipeptide<br />
[[3fgd]] - TML residues 233-548+dipeptide<br />
- 
=== TML+inhibitor ===
=== TML+inhibitor ===
- 
[[1fjo]], [[1fj3]], [[1fjq]], [[1fjt]], [[1fju]], [[1fjv]], [[1fjw]], [[4tli]], [[5tli]], [[6tli]], [[7tli]], [[8tli]], [[1tli]], [[2tli]], [[3tli]] – TML soaked in organic solvents<br />
[[1fjo]], [[1fj3]], [[1fjq]], [[1fjt]], [[1fju]], [[1fjv]], [[1fjw]], [[4tli]], [[5tli]], [[6tli]], [[7tli]], [[8tli]], [[1tli]], [[2tli]], [[3tli]] – TML soaked in organic solvents<br />
[[3fv4]], [[3fxp]], [[3flf]], [[3fb0]], [[3fcq]], [[3f28]], [[3f2p]] – TML residues 233-548+inhibitor<br />
[[3fv4]], [[3fxp]], [[3flf]], [[3fb0]], [[3fcq]], [[3f28]], [[3f2p]] – TML residues 233-548+inhibitor<br />
[[3fwd]], [[3for]], [[1y3g]], [[1zdp]], [[1z9g]], [[1pes]], [[1pe7]], [[1pe8]], [[1os0]], [[1kto]], [[1ks7]], [[1kro]], [[1kr6]], [[1kkk]], [[1kjo]], [[1kjp]], [[1qf0]], [[1qf1]], [[1qf2]], [[1hyt]], [[1thl]], [[6tmn]], [[7tln]], [[4tln]], [[5tln]], [[1pe5]], [[3ms3]], [[3msa]], [[3msf]], [[3msn]], [[3n21]], [[3nn7]] – TML+inhibitor<br />
[[3fwd]], [[3for]], [[1y3g]], [[1zdp]], [[1z9g]], [[1pes]], [[1pe7]], [[1pe8]], [[1os0]], [[1kto]], [[1ks7]], [[1kro]], [[1kr6]], [[1kkk]], [[1kjo]], [[1kjp]], [[1qf0]], [[1qf1]], [[1qf2]], [[1hyt]], [[1thl]], [[6tmn]], [[7tln]], [[4tln]], [[5tln]], [[1pe5]], [[3ms3]], [[3msa]], [[3msf]], [[3msn]], [[3n21]], [[3nn7]] – TML+inhibitor<br />
-
[[3ssb]] – TML + Impi-α
+
[[3ssb]] – TML + Impi-α<br />
 +
[[3t2h]] – TML + trimethylamine oxide<br />
 +
[[3t2i]] – TML + sarcosine<br />
 +
[[3t2j]] – TML + betaine
</StructureSection>
</StructureSection>

Revision as of 07:44, 3 July 2012

PDB ID 2a7g

Drag the structure with the mouse to rotate

References

  1. ↑ Matthews, BW. (1988): Structural basis of the action of thermolysin and related zinc peptidases. In: Acc. Chem. Res. 21(9); 333–340; http://dx.doi.org/10.1021/ar00153a003
  2. ↑ Pelmenschikov V, Blomberg MR, Siegbahn PE. A theoretical study of the mechanism for peptide hydrolysis by thermolysin. J Biol Inorg Chem. 2002 Mar;7(3):284-98. Epub 2001 Sep 27. PMID:11935352 doi:http://dx.doi.org/10.1007/s007750100295


Created with the participation of Ralf Stephan.

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/Thermolysin"
Personal tools