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4dpf

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'''Unreleased structure'''
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[[Image:4dpf.jpg|left|200px]]
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The entry 4dpf is ON HOLD until Paper Publication
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{{STRUCTURE_4dpf| PDB=4dpf | SCENE= }}
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Authors: Lindberg, J., Borkakoti, N., Derbyshire, D.
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===BACE-1 in complex with a HEA-macrocyclic type inhibitor===
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Description: BACE-1 in complex with a HEA-macrocyclic type inhibitor
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{{ABSTRACT_PUBMED_22698785}}
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==About this Structure==
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[[4dpf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DPF OCA].
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==Reference==
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<ref group="xtra">PMID:022698785</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Memapsin 2]]
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[[Category: Borkakoti, N.]]
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[[Category: Derbyshire, D.]]
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[[Category: Lindberg, J.]]
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[[Category: Asp2]]
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[[Category: Bace]]
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[[Category: Bace1]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Macrocycle]]

Revision as of 08:12, 11 July 2012

Image:4dpf.jpg

Template:STRUCTURE 4dpf

BACE-1 in complex with a HEA-macrocyclic type inhibitor

Template:ABSTRACT PUBMED 22698785

About this Structure

4dpf is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Sandgren V, Agback T, Johansson PO, Lindberg J, Kvarnstrom I, Samuelsson B, Belda O, Dahlgren A. Highly potent macrocyclic BACE-1 inhibitors incorporating a hydroxyethylamine core: Design, synthesis and X-ray crystal structures of enzyme inhibitor complexes. Bioorg Med Chem. 2012 Jul 15;20(14):4377-89. Epub 2012 May 24. PMID:22698785 doi:10.1016/j.bmc.2012.05.039

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OCA

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