1a5e
From Proteopedia
(New page: 200px<br /> <applet load="1a5e" size="450" color="white" frame="true" align="right" spinBox="true" caption="1a5e" /> '''SOLUTION NMR STRUCTURE OF TUMOR SUPPRESSOR ...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1a5e.gif|left|200px]]<br /> | + | [[Image:1a5e.gif|left|200px]]<br /><applet load="1a5e" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1a5e" size=" | + | |
caption="1a5e" /> | caption="1a5e" /> | ||
'''SOLUTION NMR STRUCTURE OF TUMOR SUPPRESSOR P16INK4A, 18 STRUCTURES'''<br /> | '''SOLUTION NMR STRUCTURE OF TUMOR SUPPRESSOR P16INK4A, 18 STRUCTURES'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The solution structure of the tumor suppressor p16INK4A has been | + | The solution structure of the tumor suppressor p16INK4A has been determined by NMR, and important recognition regions of both cdk4 and p16INK4A have been identified. The tertiary structure of p16INK4A contains four helix-turn-helix motifs linked by three loops. Twelve tumorigenic mutants of p16INK4A have been constructed and analyzed for their structure and activity, and new mutants have been designed rationally. A fragment of 58 residues at the N terminus of cdk4 important for p16INK4A binding has been identified. The importance of this region was further verified by mutational analysis of cdk4. These results and docking experiments have been used to assess possible modes of binding between p16INK4A and cdk4. |
==Disease== | ==Disease== | ||
| Line 11: | Line 10: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1A5E is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1A5E is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A5E OCA]. |
==Reference== | ==Reference== | ||
| Line 17: | Line 16: | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Byeon, I | + | [[Category: Byeon, I J.L.]] |
[[Category: Ericson, K.]] | [[Category: Ericson, K.]] | ||
| - | [[Category: Kim, H | + | [[Category: Kim, H J.]] |
[[Category: Li, J.]] | [[Category: Li, J.]] | ||
| - | [[Category: Maille, P | + | [[Category: Maille, P O.]] |
| - | [[Category: Selby, T | + | [[Category: Selby, T L.]] |
[[Category: Tevelev, A.]] | [[Category: Tevelev, A.]] | ||
| - | [[Category: Tsai, M | + | [[Category: Tsai, M D.]] |
[[Category: ank repeat]] | [[Category: ank repeat]] | ||
[[Category: anti-oncogene]] | [[Category: anti-oncogene]] | ||
| Line 30: | Line 29: | ||
[[Category: repeat]] | [[Category: repeat]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:41:04 2008'' |
Revision as of 09:41, 21 February 2008
|
SOLUTION NMR STRUCTURE OF TUMOR SUPPRESSOR P16INK4A, 18 STRUCTURES
Contents |
Overview
The solution structure of the tumor suppressor p16INK4A has been determined by NMR, and important recognition regions of both cdk4 and p16INK4A have been identified. The tertiary structure of p16INK4A contains four helix-turn-helix motifs linked by three loops. Twelve tumorigenic mutants of p16INK4A have been constructed and analyzed for their structure and activity, and new mutants have been designed rationally. A fragment of 58 residues at the N terminus of cdk4 important for p16INK4A binding has been identified. The importance of this region was further verified by mutational analysis of cdk4. These results and docking experiments have been used to assess possible modes of binding between p16INK4A and cdk4.
Disease
Known diseases associated with this structure: Li Fraumeni syndrome OMIM:[600160], Melanoma and neural system tumor syndrome OMIM:[600160], Melanoma, cutaneous malignant, 2 OMIM:[600160], Orolaryngeal cancer, multiple, OMIM:[600160], Pancreatic cancer/melanoma syndrome OMIM:[600160]
About this Structure
1A5E is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Tumor suppressor p16INK4A: determination of solution structure and analyses of its interaction with cyclin-dependent kinase 4., Byeon IJ, Li J, Ericson K, Selby TL, Tevelev A, Kim HJ, O'Maille P, Tsai MD, Mol Cell. 1998 Feb;1(3):421-31. PMID:9660926
Page seeded by OCA on Thu Feb 21 11:41:04 2008
Categories: Homo sapiens | Single protein | Byeon, I J.L. | Ericson, K. | Kim, H J. | Li, J. | Maille, P O. | Selby, T L. | Tevelev, A. | Tsai, M D. | Ank repeat | Anti-oncogene | Cell cycle | Repeat
