1v0d
From Proteopedia
(New page: 200px<br /> <applet load="1v0d" size="450" color="white" frame="true" align="right" spinBox="true" caption="1v0d, resolution 2.6Å" /> '''CRYSTAL STRUCTURE OF...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1V0D is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]] with ZN, MG and PB as [[http://en.wikipedia.org/wiki/ligands ligands]]. The following page contains interesting information on the relation of 1V0D with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb56_1.html Caspases]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1V0D OCA]]. | + | 1V0D is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]] with ZN, MG and PB as [[http://en.wikipedia.org/wiki/ligands ligands]]. The following page contains interesting information on the relation of 1V0D with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb56_1.html Caspases]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1V0D OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: nuclease]] | [[Category: nuclease]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:30:59 2007'' |
Revision as of 11:26, 30 October 2007
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CRYSTAL STRUCTURE OF CASPASE-ACTIVATED DNASE (CAD)
Overview
CAD/DFF40 is responsible for the degradation of chromosomal DNA into, nucleosomal fragments and subsequent chromatin condensation during, apoptosis. It exists as an inactive complex with its inhibitor ICAD/DFF45, in proliferating cells but becomes activated upon cleavage of ICAD/DFF45, into three domains by caspases in dying cells. The molecular mechanism, underlying the control and activation of CAD/DFF40 was unknown. Here, the, crystal structure of activated CAD/DFF40 reveals that it is a pair of, molecular scissors with a deep active-site crevice that appears ideal for, distinguishing internucleosomal DNA from nucleosomal DNA. Ensuing studies, show that ICAD/DFF45 sequesters the nonfunctional CAD/DFF40 monomer and is, also able to disassemble the functional CAD/DFF40 dimer. This ... [(full description)]
About this Structure
1V0D is a [Single protein] structure of sequence from [Mus musculus] with ZN, MG and PB as [ligands]. The following page contains interesting information on the relation of 1V0D with [Caspases]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structural mechanism for inactivation and activation of CAD/DFF40 in the apoptotic pathway., Woo EJ, Kim YG, Kim MS, Han WD, Shin S, Robinson H, Park SY, Oh BH, Mol Cell. 2004 May 21;14(4):531-9. PMID:15149602
Page seeded by OCA on Tue Oct 30 13:30:59 2007
Categories: Caspases | Mus musculus | Single protein | Han, W.D. | Kim, M.S. | Kim, Y.G. | Oh, B.H. | Shin, S. | Woo, E.J. | MG | PB | ZN | Caspase-activated dnase | Hydrolase | Nuclease
