1a79
From Proteopedia
(New page: 200px<br /><applet load="1a79" size="450" color="white" frame="true" align="right" spinBox="true" caption="1a79, resolution 2.28Å" /> '''CRYSTAL STRUCTURE OF...) |
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| - | [[Image:1a79.jpg|left|200px]]<br /><applet load="1a79" size=" | + | [[Image:1a79.jpg|left|200px]]<br /><applet load="1a79" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1a79, resolution 2.28Å" /> | caption="1a79, resolution 2.28Å" /> | ||
'''CRYSTAL STRUCTURE OF THE TRNA SPLICING ENDONUCLEASE FROM METHANOCOCCUS JANNASCHII'''<br /> | '''CRYSTAL STRUCTURE OF THE TRNA SPLICING ENDONUCLEASE FROM METHANOCOCCUS JANNASCHII'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The splicing of transfer RNA precursors is similar in Eucarya and Archaea. | + | The splicing of transfer RNA precursors is similar in Eucarya and Archaea. In both kingdoms an endonuclease recognizes the splice sites and releases the intron, but the mechanism of splice site recognition is different in each kingdom. The crystal structure of the endonuclease from the archaeon Methanococcus jannaschii was determined to a resolution of 2.3 angstroms. The structure indicates that the cleavage reaction is similar to that of ribonuclease A and the arrangement of the active sites is conserved between the archaeal and eucaryal enzymes. These results suggest an evolutionary pathway for splice site recognition. |
==About this Structure== | ==About this Structure== | ||
| - | 1A79 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii] with SO4 and AU as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1A79 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=AU:'>AU</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A79 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Methanocaldococcus jannaschii]] | [[Category: Methanocaldococcus jannaschii]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Abelson, J | + | [[Category: Abelson, J N.]] |
[[Category: Li, H.]] | [[Category: Li, H.]] | ||
| - | [[Category: Trotta, C | + | [[Category: Trotta, C R.]] |
[[Category: AU]] | [[Category: AU]] | ||
[[Category: SO4]] | [[Category: SO4]] | ||
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[[Category: trna endonuclease]] | [[Category: trna endonuclease]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:41:41 2008'' |
Revision as of 09:41, 21 February 2008
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CRYSTAL STRUCTURE OF THE TRNA SPLICING ENDONUCLEASE FROM METHANOCOCCUS JANNASCHII
Overview
The splicing of transfer RNA precursors is similar in Eucarya and Archaea. In both kingdoms an endonuclease recognizes the splice sites and releases the intron, but the mechanism of splice site recognition is different in each kingdom. The crystal structure of the endonuclease from the archaeon Methanococcus jannaschii was determined to a resolution of 2.3 angstroms. The structure indicates that the cleavage reaction is similar to that of ribonuclease A and the arrangement of the active sites is conserved between the archaeal and eucaryal enzymes. These results suggest an evolutionary pathway for splice site recognition.
About this Structure
1A79 is a Single protein structure of sequence from Methanocaldococcus jannaschii with and as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structure and evolution of a transfer RNA splicing enzyme., Li H, Trotta CR, Abelson J, Science. 1998 Apr 10;280(5361):279-84. PMID:9535656
Page seeded by OCA on Thu Feb 21 11:41:41 2008
