1a8o
From Proteopedia
(New page: 200px<br /> <applet load="1a8o" size="450" color="white" frame="true" align="right" spinBox="true" caption="1a8o, resolution 1.70Å" /> '''HIV CAPSID C-TERMIN...) |
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| - | [[Image:1a8o.gif|left|200px]]<br /> | + | [[Image:1a8o.gif|left|200px]]<br /><applet load="1a8o" size="350" color="white" frame="true" align="right" spinBox="true" |
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caption="1a8o, resolution 1.70Å" /> | caption="1a8o, resolution 1.70Å" /> | ||
'''HIV CAPSID C-TERMINAL DOMAIN'''<br /> | '''HIV CAPSID C-TERMINAL DOMAIN'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The carboxyl-terminal domain, residues 146 to 231, of the human | + | The carboxyl-terminal domain, residues 146 to 231, of the human immunodeficiency virus-1 (HIV-1) capsid protein [CA(146-231)] is required for capsid dimerization and viral assembly. This domain contains a stretch of 20 residues, called the major homology region (MHR), which is conserved across retroviruses and is essential for viral assembly, maturation, and infectivity. The crystal structures of CA(146-231) and CA(151-231) reveal that the globular domain is composed of four helices and an extended amino-terminal strand. CA(146-231) dimerizes through parallel packing of helix 2 across a dyad. The MHR is distinct from the dimer interface and instead forms an intricate hydrogen-bonding network that interconnects strand 1 and helices 1 and 2. Alignment of the CA(146-231) dimer with the crystal structure of the capsid amino-terminal domain provides a model for the intact protein and extends models for assembly of the central conical core of HIV-1. |
==About this Structure== | ==About this Structure== | ||
| - | 1A8O is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. This structure | + | 1A8O is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. This structure supersedes the now removed PDB entry 1AM3. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A8O OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Human immunodeficiency virus 1]] | [[Category: Human immunodeficiency virus 1]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Gamble, T | + | [[Category: Gamble, T R.]] |
| - | [[Category: Hill, C | + | [[Category: Hill, C P.]] |
| - | [[Category: Mccutcheon, J | + | [[Category: Mccutcheon, J P.]] |
| - | [[Category: Schwedler, U | + | [[Category: Schwedler, U K.Von.]] |
| - | [[Category: Sundquist, W | + | [[Category: Sundquist, W I.]] |
| - | [[Category: Vajdos, F | + | [[Category: Vajdos, F F.]] |
[[Category: Wang, H.]] | [[Category: Wang, H.]] | ||
| - | [[Category: Worthylake, D | + | [[Category: Worthylake, D K.]] |
[[Category: Yoo, S.]] | [[Category: Yoo, S.]] | ||
[[Category: c-terminal domain]] | [[Category: c-terminal domain]] | ||
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[[Category: hiv]] | [[Category: hiv]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:42:05 2008'' |
Revision as of 09:42, 21 February 2008
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HIV CAPSID C-TERMINAL DOMAIN
Overview
The carboxyl-terminal domain, residues 146 to 231, of the human immunodeficiency virus-1 (HIV-1) capsid protein [CA(146-231)] is required for capsid dimerization and viral assembly. This domain contains a stretch of 20 residues, called the major homology region (MHR), which is conserved across retroviruses and is essential for viral assembly, maturation, and infectivity. The crystal structures of CA(146-231) and CA(151-231) reveal that the globular domain is composed of four helices and an extended amino-terminal strand. CA(146-231) dimerizes through parallel packing of helix 2 across a dyad. The MHR is distinct from the dimer interface and instead forms an intricate hydrogen-bonding network that interconnects strand 1 and helices 1 and 2. Alignment of the CA(146-231) dimer with the crystal structure of the capsid amino-terminal domain provides a model for the intact protein and extends models for assembly of the central conical core of HIV-1.
About this Structure
1A8O is a Single protein structure of sequence from Human immunodeficiency virus 1. This structure supersedes the now removed PDB entry 1AM3. Full crystallographic information is available from OCA.
Reference
Structure of the carboxyl-terminal dimerization domain of the HIV-1 capsid protein., Gamble TR, Yoo S, Vajdos FF, von Schwedler UK, Worthylake DK, Wang H, McCutcheon JP, Sundquist WI, Hill CP, Science. 1997 Oct 31;278(5339):849-53. PMID:9346481
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