1m6x
From Proteopedia
(New page: 200px<br /> <applet load="1m6x" size="450" color="white" frame="true" align="right" spinBox="true" caption="1m6x, resolution 2.80Å" /> '''Flpe-Holliday Junct...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1M6X is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1M6X OCA]]. | + | 1M6X is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]]. Structure known Active Sites: CTA, CTB, CTC and CTD. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1M6X OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: tyrosine recombinase]] | [[Category: tyrosine recombinase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:31:29 2007'' |
Revision as of 11:26, 30 October 2007
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Flpe-Holliday Junction Complex
Overview
The Flp recombinase, a member of the lambda integrase or tyrosine-based, family of site-specific recombinases, is an interesting example of an, enzyme whose catalytic activity is regulated by protein-protein contacts., It exhibits half-of-the-sites activity throughout its catalytic cycle. Flp, is unique among these recombinases, in that it assembles each active site, in trans through the interaction of two protein monomers within the, catalytic tetramer, with isomerization of interacting pairs being, essential to complete a full reaction. We report here the structure of a, DNA-bound tetramer of Flpe, a variant of Flp that is more active at 37, degrees C than the wild-type recombinase. This new structure includes the, first observation of a tyrosine recombinase with an invading 5'-OH ... [(full description)]
About this Structure
1M6X is a [Protein complex] structure of sequences from [Saccharomyces cerevisiae]. Structure known Active Sites: CTA, CTB, CTC and CTD. Full crystallographic information is available from [OCA].
Reference
Structural plasticity of the Flp-Holliday junction complex., Conway AB, Chen Y, Rice PA, J Mol Biol. 2003 Feb 14;326(2):425-34. PMID:12559911
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