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1w08

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(New page: 200px<br /> <applet load="1w08" size="450" color="white" frame="true" align="right" spinBox="true" caption="1w08, resolution 2.5&Aring;" /> '''STRUCTURE OF T70N HU...)
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==About this Structure==
==About this Structure==
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1W08 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with CL as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W08 OCA]].
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1W08 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with CL as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Lysozyme Lysozyme]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W08 OCA]].
==Reference==
==Reference==
Rationalising lysozyme amyloidosis: insights from the structure and solution dynamics of T70N lysozyme., Johnson RJ, Christodoulou J, Dumoulin M, Caddy GL, Alcocer MJ, Murtagh GJ, Kumita JR, Larsson G, Robinson CV, Archer DB, Luisi B, Dobson CM, J Mol Biol. 2005 Sep 30;352(4):823-36. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16126226 16126226]
Rationalising lysozyme amyloidosis: insights from the structure and solution dynamics of T70N lysozyme., Johnson RJ, Christodoulou J, Dumoulin M, Caddy GL, Alcocer MJ, Murtagh GJ, Kumita JR, Larsson G, Robinson CV, Archer DB, Luisi B, Dobson CM, J Mol Biol. 2005 Sep 30;352(4):823-36. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16126226 16126226]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Lysozyme]]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Alcocer, M.]]
[[Category: Alcocer, M.]]
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[[Category: o-glycosyl]]
[[Category: o-glycosyl]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 20:44:00 2007''
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:32:03 2007''

Revision as of 11:27, 30 October 2007

Image:1w08.gif

1w08, resolution 2.5Å

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STRUCTURE OF T70N HUMAN LYSOZYME

Overview

T70N human lysozyme is the only known naturally occurring destabilised, lysozyme variant that has not been detected in amyloid deposits in human, patients. Its study and a comparison of its properties with those of the, amyloidogenic variants of lysozyme is therefore important for, understanding the determinants of amyloid disease. We report here the, X-ray crystal structure and the solution dynamics of T70N lysozyme, as, monitored by hydrogen/deuterium exchange and NMR relaxation experiments., The X-ray crystal structure shows that a substantial structural, rearrangement results from the amino acid substitution, involving residues, 45-51 and 68-75 in particular, and gives rise to a concomitant separation, of these two loops of up to 6.5A. A marked decrease in the magnitudes of, the ... [(full description)]

About this Structure

1W08 is a [Single protein] structure of sequence from [Homo sapiens] with CL as [ligand]. Active as [Lysozyme], with EC number [3.2.1.17]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

Rationalising lysozyme amyloidosis: insights from the structure and solution dynamics of T70N lysozyme., Johnson RJ, Christodoulou J, Dumoulin M, Caddy GL, Alcocer MJ, Murtagh GJ, Kumita JR, Larsson G, Robinson CV, Archer DB, Luisi B, Dobson CM, J Mol Biol. 2005 Sep 30;352(4):823-36. PMID:16126226

Page seeded by OCA on Tue Oct 30 13:32:03 2007

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