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1agq
From Proteopedia
(New page: 200px<br /><applet load="1agq" size="450" color="white" frame="true" align="right" spinBox="true" caption="1agq, resolution 1.90Å" /> '''GLIAL CELL-DERIVED N...) |
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| - | [[Image:1agq.gif|left|200px]]<br /><applet load="1agq" size=" | + | [[Image:1agq.gif|left|200px]]<br /><applet load="1agq" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1agq, resolution 1.90Å" /> | caption="1agq, resolution 1.90Å" /> | ||
'''GLIAL CELL-DERIVED NEUROTROPHIC FACTOR FROM RAT'''<br /> | '''GLIAL CELL-DERIVED NEUROTROPHIC FACTOR FROM RAT'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The crystal structure of glial cell-derived neurotrophic factor (GDNF) | + | The crystal structure of glial cell-derived neurotrophic factor (GDNF) reveals two independent copies of the dimer that differ significantly through a hinge bending at the central, disulphide-rich region. GDNF is compared with other members of the TGF-beta family, and potential receptor binding surfaces are identified. |
==About this Structure== | ==About this Structure== | ||
| - | 1AGQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http:// | + | 1AGQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AGQ OCA]. |
==Reference== | ==Reference== | ||
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[[Category: neurotrophic factor]] | [[Category: neurotrophic factor]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:44:21 2008'' |
Revision as of 09:44, 21 February 2008
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GLIAL CELL-DERIVED NEUROTROPHIC FACTOR FROM RAT
Overview
The crystal structure of glial cell-derived neurotrophic factor (GDNF) reveals two independent copies of the dimer that differ significantly through a hinge bending at the central, disulphide-rich region. GDNF is compared with other members of the TGF-beta family, and potential receptor binding surfaces are identified.
About this Structure
1AGQ is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
X-ray structure of glial cell-derived neurotrophic factor at 1.9 A resolution and implications for receptor binding., Eigenbrot C, Gerber N, Nat Struct Biol. 1997 Jun;4(6):435-8. PMID:9187648
Page seeded by OCA on Thu Feb 21 11:44:21 2008
