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1aol
From Proteopedia
(New page: 200px<br /><applet load="1aol" size="450" color="white" frame="true" align="right" spinBox="true" caption="1aol, resolution 2.0Å" /> '''FRIEND MURINE LEUKEMI...) |
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| - | [[Image:1aol.gif|left|200px]]<br /><applet load="1aol" size=" | + | [[Image:1aol.gif|left|200px]]<br /><applet load="1aol" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1aol, resolution 2.0Å" /> | caption="1aol, resolution 2.0Å" /> | ||
'''FRIEND MURINE LEUKEMIA VIRUS RECEPTOR-BINDING DOMAIN'''<br /> | '''FRIEND MURINE LEUKEMIA VIRUS RECEPTOR-BINDING DOMAIN'''<br /> | ||
==Overview== | ==Overview== | ||
| - | An essential step in retrovirus infection is the binding of the virus to | + | An essential step in retrovirus infection is the binding of the virus to its receptor on a target cell. The structure of the receptor-binding domain of the envelope glycoprotein from Friend murine leukemia virus was determined to 2.0 angstrom resolution by x-ray crystallography. The core of the domain is an antiparallel beta sandwich, with two interstrand loops forming a helical subdomain atop the sandwich. The residues in the helical region, but not in the beta sandwich, are highly variable among mammalian C-type retroviruses with distinct tropisms, indicating that the helical subdomain determines the receptor specificity of the virus. |
==About this Structure== | ==About this Structure== | ||
| - | 1AOL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Friend_murine_leukemia_virus Friend murine leukemia virus] with NAG and ZN as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1AOL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Friend_murine_leukemia_virus Friend murine leukemia virus] with <scene name='pdbligand=NAG:'>NAG</scene> and <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AOL OCA]. |
==Reference== | ==Reference== | ||
| Line 13: | Line 13: | ||
[[Category: Friend murine leukemia virus]] | [[Category: Friend murine leukemia virus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Berger, J | + | [[Category: Berger, J M.]] |
| - | [[Category: Cunningham, J | + | [[Category: Cunningham, J M.]] |
| - | [[Category: Davey, R | + | [[Category: Davey, R A.]] |
[[Category: Fass, D.]] | [[Category: Fass, D.]] | ||
| - | [[Category: Hamson, C | + | [[Category: Hamson, C A.]] |
| - | [[Category: Kim, P | + | [[Category: Kim, P S.]] |
[[Category: NAG]] | [[Category: NAG]] | ||
[[Category: ZN]] | [[Category: ZN]] | ||
| Line 25: | Line 25: | ||
[[Category: viral glycoprotein]] | [[Category: viral glycoprotein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:46:41 2008'' |
Revision as of 09:46, 21 February 2008
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FRIEND MURINE LEUKEMIA VIRUS RECEPTOR-BINDING DOMAIN
Overview
An essential step in retrovirus infection is the binding of the virus to its receptor on a target cell. The structure of the receptor-binding domain of the envelope glycoprotein from Friend murine leukemia virus was determined to 2.0 angstrom resolution by x-ray crystallography. The core of the domain is an antiparallel beta sandwich, with two interstrand loops forming a helical subdomain atop the sandwich. The residues in the helical region, but not in the beta sandwich, are highly variable among mammalian C-type retroviruses with distinct tropisms, indicating that the helical subdomain determines the receptor specificity of the virus.
About this Structure
1AOL is a Single protein structure of sequence from Friend murine leukemia virus with and as ligands. Full crystallographic information is available from OCA.
Reference
Structure of a murine leukemia virus receptor-binding glycoprotein at 2.0 angstrom resolution., Fass D, Davey RA, Hamson CA, Kim PS, Cunningham JM, Berger JM, Science. 1997 Sep 12;277(5332):1662-6. PMID:9287219
Page seeded by OCA on Thu Feb 21 11:46:41 2008
