1ap0
From Proteopedia
(New page: 200px<br /><applet load="1ap0" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ap0" /> '''STRUCTURE OF THE CHROMATIN BINDING (CHROMO) ...) |
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| - | [[Image:1ap0.gif|left|200px]]<br /><applet load="1ap0" size=" | + | [[Image:1ap0.gif|left|200px]]<br /><applet load="1ap0" size="350" color="white" frame="true" align="right" spinBox="true" |
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'''STRUCTURE OF THE CHROMATIN BINDING (CHROMO) DOMAIN FROM MOUSE MODIFIER PROTEIN 1, NMR, 26 STRUCTURES'''<br /> | '''STRUCTURE OF THE CHROMATIN BINDING (CHROMO) DOMAIN FROM MOUSE MODIFIER PROTEIN 1, NMR, 26 STRUCTURES'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The structure of a chromatin binding domain from mouse chromatin modifier | + | The structure of a chromatin binding domain from mouse chromatin modifier protein 1 (MoMOD1) was determined using nuclear magnetic resonance (NMR) spectroscopy. The protein consists of an N-terminal three-stranded anti-parallel beta-sheet which folds against a C-terminal alpha-helix. The structure reveals an unexpected homology to two archaebacterial DNA binding proteins which are also involved in chromatin structure. Structural comparisons suggest that chromo domains, of which more than 40 are now known, act as protein interaction motifs and that the MoMOD1 protein acts as an adaptor mediating interactions between different proteins. |
==About this Structure== | ==About this Structure== | ||
| - | 1AP0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http:// | + | 1AP0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AP0 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Archer, S | + | [[Category: Archer, S J.]] |
| - | [[Category: Ball, L | + | [[Category: Ball, L J.]] |
| - | [[Category: Broadhurst, R | + | [[Category: Broadhurst, R W.]] |
| - | [[Category: Domaille, P | + | [[Category: Domaille, P J.]] |
| - | [[Category: Laue, E | + | [[Category: Laue, E D.]] |
| - | [[Category: Murzin, A | + | [[Category: Murzin, A G.]] |
| - | [[Category: Murzina, N | + | [[Category: Murzina, N V.]] |
| - | [[Category: Raine, A | + | [[Category: Raine, A R.C.]] |
| - | [[Category: Singh, P | + | [[Category: Singh, P B.]] |
| - | [[Category: Stott, F | + | [[Category: Stott, F J.]] |
[[Category: alpha+beta]] | [[Category: alpha+beta]] | ||
[[Category: chromatin-binding]] | [[Category: chromatin-binding]] | ||
[[Category: protein interaction motif]] | [[Category: protein interaction motif]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:46:53 2008'' |
Revision as of 09:46, 21 February 2008
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STRUCTURE OF THE CHROMATIN BINDING (CHROMO) DOMAIN FROM MOUSE MODIFIER PROTEIN 1, NMR, 26 STRUCTURES
Overview
The structure of a chromatin binding domain from mouse chromatin modifier protein 1 (MoMOD1) was determined using nuclear magnetic resonance (NMR) spectroscopy. The protein consists of an N-terminal three-stranded anti-parallel beta-sheet which folds against a C-terminal alpha-helix. The structure reveals an unexpected homology to two archaebacterial DNA binding proteins which are also involved in chromatin structure. Structural comparisons suggest that chromo domains, of which more than 40 are now known, act as protein interaction motifs and that the MoMOD1 protein acts as an adaptor mediating interactions between different proteins.
About this Structure
1AP0 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Structure of the chromatin binding (chromo) domain from mouse modifier protein 1., Ball LJ, Murzina NV, Broadhurst RW, Raine AR, Archer SJ, Stott FJ, Murzin AG, Singh PB, Domaille PJ, Laue ED, EMBO J. 1997 May 1;16(9):2473-81. PMID:9171360
Page seeded by OCA on Thu Feb 21 11:46:53 2008
