1awc
From Proteopedia
(New page: 200px<br /><applet load="1awc" size="450" color="white" frame="true" align="right" spinBox="true" caption="1awc, resolution 2.150Å" /> '''MOUSE GABP ALPHA/BE...) |
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| - | [[Image:1awc.gif|left|200px]]<br /><applet load="1awc" size=" | + | [[Image:1awc.gif|left|200px]]<br /><applet load="1awc" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1awc, resolution 2.150Å" /> | caption="1awc, resolution 2.150Å" /> | ||
'''MOUSE GABP ALPHA/BETA DOMAIN BOUND TO DNA'''<br /> | '''MOUSE GABP ALPHA/BETA DOMAIN BOUND TO DNA'''<br /> | ||
==Overview== | ==Overview== | ||
| - | GA-binding protein (GABP) is a transcriptional regulator composed of two | + | GA-binding protein (GABP) is a transcriptional regulator composed of two structurally dissimilar subunits. The alpha subunit contains a DNA-binding domain that is a member of the ETS family, whereas the beta subunit contains a series of ankyrin repeats. The crystal structure of a ternary complex containing a GABPalpha/beta ETS domain-ankyrin repeat heterodimer bound to DNA was determined at 2. 15 angstrom resolution. The structure shows how an ETS domain protein can recruit a partner protein using both the ETS domain and a carboxyl-terminal extension and provides a view of an extensive protein-protein interface formed by a set of ankyrin repeats. The structure also reveals how the GABPalpha ETS domain binds to its core GGA DNA-recognition motif. |
==About this Structure== | ==About this Structure== | ||
| - | 1AWC is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http:// | + | 1AWC is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AWC OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Batchelor, A | + | [[Category: Batchelor, A H.]] |
[[Category: Wolberger, C.]] | [[Category: Wolberger, C.]] | ||
[[Category: ankyrin repeats]] | [[Category: ankyrin repeats]] | ||
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[[Category: transcription factor]] | [[Category: transcription factor]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:48:55 2008'' |
Revision as of 09:48, 21 February 2008
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MOUSE GABP ALPHA/BETA DOMAIN BOUND TO DNA
Overview
GA-binding protein (GABP) is a transcriptional regulator composed of two structurally dissimilar subunits. The alpha subunit contains a DNA-binding domain that is a member of the ETS family, whereas the beta subunit contains a series of ankyrin repeats. The crystal structure of a ternary complex containing a GABPalpha/beta ETS domain-ankyrin repeat heterodimer bound to DNA was determined at 2. 15 angstrom resolution. The structure shows how an ETS domain protein can recruit a partner protein using both the ETS domain and a carboxyl-terminal extension and provides a view of an extensive protein-protein interface formed by a set of ankyrin repeats. The structure also reveals how the GABPalpha ETS domain binds to its core GGA DNA-recognition motif.
About this Structure
1AWC is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.
Reference
The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA., Batchelor AH, Piper DE, de la Brousse FC, McKnight SL, Wolberger C, Science. 1998 Feb 13;279(5353):1037-41. PMID:9461436
Page seeded by OCA on Thu Feb 21 11:48:55 2008
