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2ce7

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(New page: 200px<br /> <applet load="2ce7" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ce7, resolution 2.44&Aring;" /> '''EDTA TREATED'''<br ...)
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==About this Structure==
==About this Structure==
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2CE7 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]] with ZN, MG and ADP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CE7 OCA]].
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2CE7 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]] with ZN, MG and ADP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CE7 OCA]].
==Reference==
==Reference==
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[[Category: metalloprotease]]
[[Category: metalloprotease]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 20:52:55 2007''
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:38:35 2007''

Revision as of 11:33, 30 October 2007

Image:2ce7.gif

2ce7, resolution 2.44Å

Drag the structure with the mouse to rotate

EDTA TREATED

Overview

The ATP-dependent integral membrane protease FtsH is universally conserved, in bacteria. Orthologs exist in chloroplasts and mitochondria, where in, humans the loss of a close FtsH-homolog causes a form of spastic, paraplegia. FtsH plays a crucial role in quality control by degrading, unneeded or damaged membrane proteins, but it also targets soluble, signaling factors like sigma(32) and lambda-CII. We report here the, crystal structure of a soluble FtsH construct that is functional in, caseinolytic and ATPase assays. The molecular architecture of this, hexameric molecule consists of two rings where the protease domains, possess an all-helical fold and form a flat hexagon that is covered by a, toroid built by the AAA domains. The active site of the protease, classifies FtsH as an ... [(full description)]

About this Structure

2CE7 is a [Single protein] structure of sequence from [Thermotoga maritima] with ZN, MG and ADP as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

The molecular architecture of the metalloprotease FtsH., Bieniossek C, Schalch T, Bumann M, Meister M, Meier R, Baumann U, Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3066-71. Epub 2006 Feb 16. PMID:16484367

Page seeded by OCA on Tue Oct 30 13:38:35 2007

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