This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2cea

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /> <applet load="2cea" size="450" color="white" frame="true" align="right" spinBox="true" caption="2cea, resolution 2.75&Aring;" /> '''WILDTYPE'''<br /> ...)
Line 8: Line 8:
==About this Structure==
==About this Structure==
-
2CEA is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]] with ZN, MG and ADP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CEA OCA]].
+
2CEA is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]] with ZN, MG and ADP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CEA OCA]].
==Reference==
==Reference==
Line 24: Line 24:
[[Category: metalloprotease]]
[[Category: metalloprotease]]
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 20:53:22 2007''
+
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:38:56 2007''

Revision as of 11:34, 30 October 2007

Image:2cea.gif

2cea, resolution 2.75Å

Drag the structure with the mouse to rotate

WILDTYPE

Overview

The ATP-dependent integral membrane protease FtsH is universally conserved, in bacteria. Orthologs exist in chloroplasts and mitochondria, where in, humans the loss of a close FtsH-homolog causes a form of spastic, paraplegia. FtsH plays a crucial role in quality control by degrading, unneeded or damaged membrane proteins, but it also targets soluble, signaling factors like sigma(32) and lambda-CII. We report here the, crystal structure of a soluble FtsH construct that is functional in, caseinolytic and ATPase assays. The molecular architecture of this, hexameric molecule consists of two rings where the protease domains, possess an all-helical fold and form a flat hexagon that is covered by a, toroid built by the AAA domains. The active site of the protease, classifies FtsH as an ... [(full description)]

About this Structure

2CEA is a [Single protein] structure of sequence from [Thermotoga maritima] with ZN, MG and ADP as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

The molecular architecture of the metalloprotease FtsH., Bieniossek C, Schalch T, Bumann M, Meister M, Meier R, Baumann U, Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3066-71. Epub 2006 Feb 16. PMID:16484367

Page seeded by OCA on Tue Oct 30 13:38:56 2007

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2cea"
Personal tools