1bg3
From Proteopedia
(New page: 200px<br /><applet load="1bg3" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bg3, resolution 2.8Å" /> '''RAT BRAIN HEXOKINASE ...) |
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| - | [[Image:1bg3.gif|left|200px]]<br /><applet load="1bg3" size=" | + | [[Image:1bg3.gif|left|200px]]<br /><applet load="1bg3" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1bg3, resolution 2.8Å" /> | caption="1bg3, resolution 2.8Å" /> | ||
'''RAT BRAIN HEXOKINASE TYPE I COMPLEX WITH GLUCOSE AND INHIBITOR GLUCOSE-6-PHOSPHATE'''<br /> | '''RAT BRAIN HEXOKINASE TYPE I COMPLEX WITH GLUCOSE AND INHIBITOR GLUCOSE-6-PHOSPHATE'''<br /> | ||
==Overview== | ==Overview== | ||
| - | We have determined the structures of the glucose-6-phosphate | + | We have determined the structures of the glucose-6-phosphate (G6P)-inhibitable 100,000 Mr Type I hexokinase from rat and the G6P-sensitive 50,000 Mr hexokinase from Schistosoma mansoni at a resolution of 2.8 and 2.6 A respectively. The structures define the glucose and G6P binding sites in these enzymes, suggest the mechanisms of intradomain G6P inhibition and activity loss in the Type I hexokinase N-terminal half, and reveal the structure of the membrane targeting motif that integrates the Type I hexokinase into the outer mitochondrial membrane. |
==About this Structure== | ==About this Structure== | ||
| - | 1BG3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with GLC, G6P and CA as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Hexokinase Hexokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.1 2.7.1.1] Full crystallographic information is available from [http:// | + | 1BG3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=GLC:'>GLC</scene>, <scene name='pdbligand=G6P:'>G6P</scene> and <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Hexokinase Hexokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.1 2.7.1.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BG3 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Garavito, R | + | [[Category: Garavito, R M.]] |
| - | [[Category: Mulichak, A | + | [[Category: Mulichak, A M.]] |
[[Category: CA]] | [[Category: CA]] | ||
[[Category: G6P]] | [[Category: G6P]] | ||
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[[Category: phosphotransferase]] | [[Category: phosphotransferase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:54:52 2008'' |
Revision as of 09:54, 21 February 2008
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RAT BRAIN HEXOKINASE TYPE I COMPLEX WITH GLUCOSE AND INHIBITOR GLUCOSE-6-PHOSPHATE
Overview
We have determined the structures of the glucose-6-phosphate (G6P)-inhibitable 100,000 Mr Type I hexokinase from rat and the G6P-sensitive 50,000 Mr hexokinase from Schistosoma mansoni at a resolution of 2.8 and 2.6 A respectively. The structures define the glucose and G6P binding sites in these enzymes, suggest the mechanisms of intradomain G6P inhibition and activity loss in the Type I hexokinase N-terminal half, and reveal the structure of the membrane targeting motif that integrates the Type I hexokinase into the outer mitochondrial membrane.
About this Structure
1BG3 is a Single protein structure of sequence from Rattus norvegicus with , and as ligands. Active as Hexokinase, with EC number 2.7.1.1 Full crystallographic information is available from OCA.
Reference
The structure of mammalian hexokinase-1., Mulichak AM, Wilson JE, Padmanabhan K, Garavito RM, Nat Struct Biol. 1998 Jul;5(7):555-60. PMID:9665168
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