2i5j
From Proteopedia
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[[Image:2i5j.png|left|200px]] | [[Image:2i5j.png|left|200px]] | ||
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===Crystal structure of HIV-1 reverse transcriptase (RT) in complex with DHBNH, an RNASE H inhibitor=== | ===Crystal structure of HIV-1 reverse transcriptase (RT) in complex with DHBNH, an RNASE H inhibitor=== | ||
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==See Also== | ==See Also== | ||
| - | *[[Reverse transcriptase]] | + | *[[Reverse transcriptase|Reverse transcriptase]] |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:017184135</ref><ref group="xtra">PMID:016302798</ref><ref group="xtra">PMID:011250910</ref><references group="xtra"/> |
[[Category: Human immunodeficiency virus 1]] | [[Category: Human immunodeficiency virus 1]] | ||
[[Category: RNA-directed DNA polymerase]] | [[Category: RNA-directed DNA polymerase]] | ||
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[[Category: Sarafianos, S G.]] | [[Category: Sarafianos, S G.]] | ||
[[Category: Aid]] | [[Category: Aid]] | ||
| - | [[Category: Crystal structure]] | ||
[[Category: Drug resistance]] | [[Category: Drug resistance]] | ||
[[Category: Hiv]] | [[Category: Hiv]] | ||
Revision as of 20:34, 25 July 2012
Contents |
Crystal structure of HIV-1 reverse transcriptase (RT) in complex with DHBNH, an RNASE H inhibitor
Template:ABSTRACT PUBMED 17184135
About this Structure
2i5j is a 2 chain structure of Reverse transcriptase with sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.
See Also
Reference
- Himmel DM, Sarafianos SG, Dharmasena S, Hossain MM, McCoy-Simandle K, Ilina T, Clark AD Jr, Knight JL, Julias JG, Clark PK, Krogh-Jespersen K, Levy RM, Hughes SH, Parniak MA, Arnold E. HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site. ACS Chem Biol. 2006 Dec 20;1(11):702-12. PMID:17184135 doi:10.1021/cb600303y
- Himmel DM, Das K, Clark AD Jr, Hughes SH, Benjahad A, Oumouch S, Guillemont J, Coupa S, Poncelet A, Csoka I, Meyer C, Andries K, Nguyen CH, Grierson DS, Arnold E. Crystal structures for HIV-1 reverse transcriptase in complexes with three pyridinone derivatives: a new class of non-nucleoside inhibitors effective against a broad range of drug-resistant strains. J Med Chem. 2005 Dec 1;48(24):7582-91. PMID:16302798 doi:10.1021/jm0500323
- Sarafianos SG, Das K, Tantillo C, Clark AD Jr, Ding J, Whitcomb JM, Boyer PL, Hughes SH, Arnold E. Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA. EMBO J. 2001 Mar 15;20(6):1449-61. PMID:11250910 doi:10.1093/emboj/20.6.1449
Categories: Human immunodeficiency virus 1 | RNA-directed DNA polymerase | Arnold, E. | Himmel, D M. | Knight, J L. | Levy, R M. | Sarafianos, S G. | Aid | Drug resistance | Hiv | Protein-inhibitor complex | Reverse transcriptase | Rnase h inhibitor | Rnhi | Rt | Structure-based drug design | Transferase
