3g0f
From Proteopedia
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[[Image:3g0f.png|left|200px]] | [[Image:3g0f.png|left|200px]] | ||
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{{STRUCTURE_3g0f| PDB=3g0f | SCENE= }} | {{STRUCTURE_3g0f| PDB=3g0f | SCENE= }} | ||
===KIT kinase domain mutant D816H in complex with sunitinib=== | ===KIT kinase domain mutant D816H in complex with sunitinib=== | ||
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| - | (as it appears on PubMed at http://www.pubmed.gov), where 19164557 is the PubMed ID number. | ||
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{{ABSTRACT_PUBMED_19164557}} | {{ABSTRACT_PUBMED_19164557}} | ||
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| - | ==Disease== | ||
| - | Known disease associated with this structure: Gastrointestinal stromal tumor, somatic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164920 164920]], Germ cell tumors OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164920 164920]], Leukemia, acute myeloid OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164920 164920]], Mast cell leukemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164920 164920]], Mastocytosis with associated hematologic disorder OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164920 164920]], Piebaldism OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164920 164920]] | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[3g0f]] is a 2 chain structure of [[Proto-oncogene tyrosine-protein kinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G0F OCA]. | |
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| + | ==See Also== | ||
| + | *[[Proto-oncogene tyrosine-protein kinase|Proto-oncogene tyrosine-protein kinase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:019164557</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Receptor protein-tyrosine kinase]] | [[Category: Receptor protein-tyrosine kinase]] | ||
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[[Category: Nucleotide-binding]] | [[Category: Nucleotide-binding]] | ||
[[Category: Phosphoprotein]] | [[Category: Phosphoprotein]] | ||
| - | [[Category: Polymorphism]] | ||
[[Category: Proto-oncogene]] | [[Category: Proto-oncogene]] | ||
[[Category: Receptor]] | [[Category: Receptor]] | ||
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[[Category: Transmembrane]] | [[Category: Transmembrane]] | ||
[[Category: Tyrosine-protein kinase]] | [[Category: Tyrosine-protein kinase]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 3 10:20:33 2009'' | ||
Revision as of 22:51, 25 July 2012
Contents |
KIT kinase domain mutant D816H in complex with sunitinib
Template:ABSTRACT PUBMED 19164557
About this Structure
3g0f is a 2 chain structure of Proto-oncogene tyrosine-protein kinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Gajiwala KS, Wu JC, Christensen J, Deshmukh GD, Diehl W, Dinitto JP, English JM, Greig MJ, He YA, Jacques SL, Lunney EA, McTigue M, Molina D, Quenzer T, Wells PA, Yu X, Zhang Y, Zou A, Emmett MR, Marshall AG, Zhang HM, Demetri GD. KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients. Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1542-7. Epub 2009 Jan 21. PMID:19164557
Categories: Homo sapiens | Receptor protein-tyrosine kinase | Demetri, G D. | Gajiwala, K S. | Lunney, E A. | Wu, J C. | Atp-binding | Disease mutation | Drug resistance | Glycoprotein | Immunoglobulin domain | Kinase | Kit kinase domain | Membrane | Nucleotide-binding | Phosphoprotein | Proto-oncogene | Receptor | Sutent binding | Transferase | Transmembrane | Tyrosine-protein kinase
