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2cjs
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(New page: 200px<br /> <applet load="2cjs" size="450" color="white" frame="true" align="right" spinBox="true" caption="2cjs, resolution 1.78Å" /> '''STRUCTURAL BASIS FO...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2CJS is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]] with ZN, EDO and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CJS OCA]]. | + | 2CJS is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]] with ZN, EDO and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CJS OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: zinc finger]] | [[Category: zinc finger]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:44:27 2007'' |
Revision as of 11:39, 30 October 2007
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STRUCTURAL BASIS FOR A MUNC13-1 HOMODIMER- MUNC13-1- RIM HETERODIMER SWITCH: C2-DOMAINS AS VERSATILE PROTEIN-PROTEIN INTERACTION MODULES
Overview
C(2) domains are well characterized as Ca(2+)/phospholipid-binding, modules, but little is known about how they mediate protein-protein, interactions. In neurons, a Munc13-1 C(2)A-domain/RIM zinc-finger domain, (ZF) heterodimer couples synaptic vesicle priming to presynaptic, plasticity. We now show that the Munc13-1 C(2)A domain homodimerizes, and, that homodimerization competes with Munc13-1/RIM heterodimerization. X-ray, diffraction studies guided by nuclear magnetic resonance (NMR) experiments, reveal the crystal structures of the Munc13-1 C(2)A-domain homodimer and, the Munc13-1 C(2)A-domain/RIM ZF heterodimer at 1.44 A and 1.78 A, resolution, respectively. The C(2)A domain adopts a beta-sandwich, structure with a four-stranded concave side that mediates, homodimerization, leading to ... [(full description)]
About this Structure
2CJS is a [Protein complex] structure of sequences from [Rattus norvegicus] with ZN, EDO and GOL as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structural basis for a Munc13-1 homodimer to Munc13-1/RIM heterodimer switch., Lu J, Machius M, Dulubova I, Dai H, Sudhof TC, Tomchick DR, Rizo J, PLoS Biol. 2006 Jun;4(7):e192. PMID:16732694
Page seeded by OCA on Tue Oct 30 13:44:27 2007
Categories: Protein complex | Rattus norvegicus | Dai, H. | Dulubova, I. | Lu, J. | Machius, M. | Rizo, J. | Sudhof, T.C. | Tomchick, D.R. | EDO | GOL | ZN | Alternative splicing | C2 domains | Coiled coil | Exocytosis | Metal-binding | Munc13 | Neurotransmitter release | Neurotransmitter transport | Phorbol-ester binding | Protein-protein interactions | Rim | Synapse | Synaptosome | Transport | Zinc | Zinc finger
