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1tl8
From Proteopedia
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[[Image:1tl8.png|left|200px]] | [[Image:1tl8.png|left|200px]] | ||
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{{STRUCTURE_1tl8| PDB=1tl8 | SCENE= }} | {{STRUCTURE_1tl8| PDB=1tl8 | SCENE= }} | ||
===Human DNA topoisomerase I (70 kDa) in complex with the indenoisoquinoline AI-III-52 and covalent complex with a 22 base pair DNA duplex=== | ===Human DNA topoisomerase I (70 kDa) in complex with the indenoisoquinoline AI-III-52 and covalent complex with a 22 base pair DNA duplex=== | ||
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{{ABSTRACT_PUBMED_16033260}} | {{ABSTRACT_PUBMED_16033260}} | ||
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==See Also== | ==See Also== | ||
| - | *[[Topoisomerase]] | + | *[[Topoisomerase|Topoisomerase]] |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:016033260</ref><references group="xtra"/> |
[[Category: DNA topoisomerase]] | [[Category: DNA topoisomerase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
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[[Category: Drug]] | [[Category: Drug]] | ||
[[Category: Idenoisoquinoline]] | [[Category: Idenoisoquinoline]] | ||
| + | [[Category: Isomerase-dna complex]] | ||
[[Category: Poison]] | [[Category: Poison]] | ||
[[Category: Topoisomerase i]] | [[Category: Topoisomerase i]] | ||
Revision as of 01:13, 26 July 2012
Contents |
Human DNA topoisomerase I (70 kDa) in complex with the indenoisoquinoline AI-III-52 and covalent complex with a 22 base pair DNA duplex
Template:ABSTRACT PUBMED 16033260
About this Structure
1tl8 is a 4 chain structure of Topoisomerase with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Ioanoviciu A, Antony S, Pommier Y, Staker BL, Stewart L, Cushman M. Synthesis and mechanism of action studies of a series of norindenoisoquinoline topoisomerase I poisons reveal an inhibitor with a flipped orientation in the ternary DNA-enzyme-inhibitor complex as determined by X-ray crystallographic analysis. J Med Chem. 2005 Jul 28;48(15):4803-14. PMID:16033260 doi:10.1021/jm050076b
