2dub
From Proteopedia
(New page: 200px<br /> <applet load="2dub" size="450" color="white" frame="true" align="right" spinBox="true" caption="2dub, resolution 2.4Å" /> '''ENOYL-COA HYDRATASE ...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2DUB is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]] with CO8 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.17 4.2.1.17]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2DUB OCA]]. | + | 2DUB is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]] with CO8 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Enoyl-CoA_hydratase Enoyl-CoA hydratase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.17 4.2.1.17]]. Structure known Active Sites: ACA, ACB, ACC, ACD, ACE and ACF. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2DUB OCA]]. |
==Reference== | ==Reference== | ||
The crystal structure of enoyl-CoA hydratase complexed with octanoyl-CoA reveals the structural adaptations required for binding of a long chain fatty acid-CoA molecule., Engel CK, Kiema TR, Hiltunen JK, Wierenga RK, J Mol Biol. 1998 Feb 6;275(5):847-59. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9480773 9480773] | The crystal structure of enoyl-CoA hydratase complexed with octanoyl-CoA reveals the structural adaptations required for binding of a long chain fatty acid-CoA molecule., Engel CK, Kiema TR, Hiltunen JK, Wierenga RK, J Mol Biol. 1998 Feb 6;275(5):847-59. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9480773 9480773] | ||
| + | [[Category: Enoyl-CoA hydratase]] | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: lyase]] | [[Category: lyase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:45:31 2007'' |
Revision as of 11:40, 30 October 2007
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ENOYL-COA HYDRATASE COMPLEXED WITH OCTANOYL-COA
Overview
The structure of the hexameric rat mitochondrial enoyl-Coenzyme A (CoA), hydratase, co-crystallised with the inhibitor octanoyl-CoA, has been, refined at a resolution of 2.4 A. Enoyl-CoA hydratase catalyses the, hydration of 2,3-unsaturated enoyl-CoA thioesters. In the crystal, structure only four of the six active sites of the hexamer in the, asymmetric unit are occupied with a ligand molecule, showing an unliganded, and a liganded active site within the same crystal form. While the protein, assembly and fold is identical to the previously solved acetoacetyl-CoA, complex, differences are observed close to the fatty acid binding pocket, due to the different nature of the ligands. The fatty acid tail of, octanoyl-CoA is bound in an extended conformation. This is possible, because a high ... [(full description)]
About this Structure
2DUB is a [Single protein] structure of sequence from [Rattus norvegicus] with CO8 as [ligand]. Active as [Enoyl-CoA hydratase], with EC number [4.2.1.17]. Structure known Active Sites: ACA, ACB, ACC, ACD, ACE and ACF. Full crystallographic information is available from [OCA].
Reference
The crystal structure of enoyl-CoA hydratase complexed with octanoyl-CoA reveals the structural adaptations required for binding of a long chain fatty acid-CoA molecule., Engel CK, Kiema TR, Hiltunen JK, Wierenga RK, J Mol Biol. 1998 Feb 6;275(5):847-59. PMID:9480773
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