1cmi

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(New page: 200px<br /> <applet load="1cmi" size="450" color="white" frame="true" align="right" spinBox="true" caption="1cmi, resolution 2.5&Aring;" /> '''STRUCTURE OF THE HUM...)
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'''STRUCTURE OF THE HUMAN PIN/LC8 DIMER WITH A BOUND PEPTIDE'''<br />
'''STRUCTURE OF THE HUMAN PIN/LC8 DIMER WITH A BOUND PEPTIDE'''<br />
==Overview==
==Overview==
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The structure of the protein known both as neuronal nitric oxide synthase, inhibitory protein, PIN (protein inhibitor of nNOS), and also as the 8 kDa, dynein light chain (LC8) has been solved by X-ray diffraction. Two PIN/LC8, monomers related by a two-fold axis form a rectangular dimer. Two pairs of, alpha-helices cover opposite faces, and each pair of helices packs against, a beta-sheet with five antiparallel beta-strands. Each five-stranded, beta-sheet contains four strands from one monomer and a fifth strand from, the other monomer. A 13-residue peptide from nNOS is bound to the dimer in, a deep hydrophobic groove as a sixth antiparallel beta-strand. The, structure provides key insights into dimerization of and peptide binding, by the multifunctional PIN/LC8 protein.
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The structure of the protein known both as neuronal nitric oxide synthase inhibitory protein, PIN (protein inhibitor of nNOS), and also as the 8 kDa dynein light chain (LC8) has been solved by X-ray diffraction. Two PIN/LC8 monomers related by a two-fold axis form a rectangular dimer. Two pairs of alpha-helices cover opposite faces, and each pair of helices packs against a beta-sheet with five antiparallel beta-strands. Each five-stranded beta-sheet contains four strands from one monomer and a fifth strand from the other monomer. A 13-residue peptide from nNOS is bound to the dimer in a deep hydrophobic groove as a sixth antiparallel beta-strand. The structure provides key insights into dimerization of and peptide binding by the multifunctional PIN/LC8 protein.
==Disease==
==Disease==
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Known diseases associated with this structure: Colorectal cancer, somatic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604258 604258]], Esophageal cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604050 604050]], HDL cholesterol level QTL 1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=606613 606613]], Lung cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604050 604050]]
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Known diseases associated with this structure: Colorectal cancer, somatic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604258 604258]], Esophageal cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604050 604050]], Lung cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604050 604050]]
==About this Structure==
==About this Structure==
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1CMI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure superseeds the now removed PDB entry 1B1W. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1CMI OCA].
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1CMI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry 1B1W. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CMI OCA].
==Reference==
==Reference==
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[[Category: pin]]
[[Category: pin]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:23:21 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:07:33 2008''

Revision as of 10:07, 21 February 2008

Image:1cmi.gif

1cmi, resolution 2.5Å

Drag the structure with the mouse to rotate

STRUCTURE OF THE HUMAN PIN/LC8 DIMER WITH A BOUND PEPTIDE

Contents

Overview

The structure of the protein known both as neuronal nitric oxide synthase inhibitory protein, PIN (protein inhibitor of nNOS), and also as the 8 kDa dynein light chain (LC8) has been solved by X-ray diffraction. Two PIN/LC8 monomers related by a two-fold axis form a rectangular dimer. Two pairs of alpha-helices cover opposite faces, and each pair of helices packs against a beta-sheet with five antiparallel beta-strands. Each five-stranded beta-sheet contains four strands from one monomer and a fifth strand from the other monomer. A 13-residue peptide from nNOS is bound to the dimer in a deep hydrophobic groove as a sixth antiparallel beta-strand. The structure provides key insights into dimerization of and peptide binding by the multifunctional PIN/LC8 protein.

Disease

Known diseases associated with this structure: Colorectal cancer, somatic OMIM:[604258], Esophageal cancer OMIM:[604050], Lung cancer OMIM:[604050]

About this Structure

1CMI is a Single protein structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 1B1W. Full crystallographic information is available from OCA.

Reference

Structure of the PIN/LC8 dimer with a bound peptide., Liang J, Jaffrey SR, Guo W, Snyder SH, Clardy J, Nat Struct Biol. 1999 Aug;6(8):735-40. PMID:10426949

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