1d2m

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /><applet load="1d2m" size="450" color="white" frame="true" align="right" spinBox="true" caption="1d2m, resolution 1.90&Aring;" /> '''UVRB PROTEIN OF THER...)
Line 1: Line 1:
-
[[Image:1d2m.jpg|left|200px]]<br /><applet load="1d2m" size="450" color="white" frame="true" align="right" spinBox="true"
+
[[Image:1d2m.jpg|left|200px]]<br /><applet load="1d2m" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1d2m, resolution 1.90&Aring;" />
caption="1d2m, resolution 1.90&Aring;" />
'''UVRB PROTEIN OF THERMUS THERMOPHILUS HB8; A NUCLEOTIDE EXCISION REPAIR ENZYME'''<br />
'''UVRB PROTEIN OF THERMUS THERMOPHILUS HB8; A NUCLEOTIDE EXCISION REPAIR ENZYME'''<br />
==Overview==
==Overview==
-
In the nucleotide excision repair system, UvrB plays a central role in, damage recognition and DNA incision by interacting with UvrA and UvrC. We, have determined the crystal structure of Thermus thermophilus HB8 UvrB at, 1.9 A resolution. UvrB comprises four domains, two of which have an, alpha/beta structure resembling the core domains of DNA and RNA helicases., Additionally, UvrB has an alpha-helical domain and a domain consisting of, antiparallel beta-sheets (beta-domain). The sequence similarity suggests, that the beta-domain interacts with UvrA. Based on the distribution of the, conserved regions and the structure of the PcrA-DNA complex, a model for, the UvrB-DNA complex is proposed.
+
In the nucleotide excision repair system, UvrB plays a central role in damage recognition and DNA incision by interacting with UvrA and UvrC. We have determined the crystal structure of Thermus thermophilus HB8 UvrB at 1.9 A resolution. UvrB comprises four domains, two of which have an alpha/beta structure resembling the core domains of DNA and RNA helicases. Additionally, UvrB has an alpha-helical domain and a domain consisting of antiparallel beta-sheets (beta-domain). The sequence similarity suggests that the beta-domain interacts with UvrA. Based on the distribution of the conserved regions and the structure of the PcrA-DNA complex, a model for the UvrB-DNA complex is proposed.
==About this Structure==
==About this Structure==
-
1D2M is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus] with BOG and SO4 as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1D2M OCA].
+
1D2M is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus] with <scene name='pdbligand=BOG:'>BOG</scene> and <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D2M OCA].
==Reference==
==Reference==
-
Crystal structure of Thermus thermophilus HB8 UvrB protein, a key enzyme of nucleotide excision repair., Nakagawa N, Sugahara M, Masui R, Kato R, Fukuyama K, Kuramitsu S, J Biochem (Tokyo). 1999 Dec;126(6):986-90. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10578047 10578047]
+
Crystal structure of Thermus thermophilus HB8 UvrB protein, a key enzyme of nucleotide excision repair., Nakagawa N, Sugahara M, Masui R, Kato R, Fukuyama K, Kuramitsu S, J Biochem. 1999 Dec;126(6):986-90. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10578047 10578047]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus]]
Line 18: Line 18:
[[Category: Masui, R.]]
[[Category: Masui, R.]]
[[Category: Nakagawa, N.]]
[[Category: Nakagawa, N.]]
-
[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
+
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Sugahara, M.]]
[[Category: Sugahara, M.]]
[[Category: BOG]]
[[Category: BOG]]
Line 27: Line 27:
[[Category: structural genomics]]
[[Category: structural genomics]]
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 12:58:10 2007''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:12:21 2008''

Revision as of 10:12, 21 February 2008

Image:1d2m.jpg

1d2m, resolution 1.90Å

Drag the structure with the mouse to rotate

UVRB PROTEIN OF THERMUS THERMOPHILUS HB8; A NUCLEOTIDE EXCISION REPAIR ENZYME

Overview

In the nucleotide excision repair system, UvrB plays a central role in damage recognition and DNA incision by interacting with UvrA and UvrC. We have determined the crystal structure of Thermus thermophilus HB8 UvrB at 1.9 A resolution. UvrB comprises four domains, two of which have an alpha/beta structure resembling the core domains of DNA and RNA helicases. Additionally, UvrB has an alpha-helical domain and a domain consisting of antiparallel beta-sheets (beta-domain). The sequence similarity suggests that the beta-domain interacts with UvrA. Based on the distribution of the conserved regions and the structure of the PcrA-DNA complex, a model for the UvrB-DNA complex is proposed.

About this Structure

1D2M is a Single protein structure of sequence from Thermus thermophilus with and as ligands. Full crystallographic information is available from OCA.

Reference

Crystal structure of Thermus thermophilus HB8 UvrB protein, a key enzyme of nucleotide excision repair., Nakagawa N, Sugahara M, Masui R, Kato R, Fukuyama K, Kuramitsu S, J Biochem. 1999 Dec;126(6):986-90. PMID:10578047

Page seeded by OCA on Thu Feb 21 12:12:21 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1d2m"
Personal tools