1d3b
From Proteopedia
(New page: 200px<br /> <applet load="1d3b" size="450" color="white" frame="true" align="right" spinBox="true" caption="1d3b, resolution 2.00Å" /> '''CRYSTAL STRUCTURE O...) |
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| - | [[Image:1d3b.gif|left|200px]]<br /> | + | [[Image:1d3b.gif|left|200px]]<br /><applet load="1d3b" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1d3b" size=" | + | |
caption="1d3b, resolution 2.00Å" /> | caption="1d3b, resolution 2.00Å" /> | ||
'''CRYSTAL STRUCTURE OF THE D3B SUBCOMPLEX OF THE HUMAN CORE SNRNP DOMAIN AT 2.0A RESOLUTION'''<br /> | '''CRYSTAL STRUCTURE OF THE D3B SUBCOMPLEX OF THE HUMAN CORE SNRNP DOMAIN AT 2.0A RESOLUTION'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles | + | The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F, and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs (snRNAs). These proteins share a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. Crystal structures of two Sm protein complexes, D3B and D1D2, show that these proteins have a common fold containing an N-terminal helix followed by a strongly bent five-stranded antiparallel beta sheet, and the D1D2 and D3B dimers superpose closely in their core regions, including the dimer interfaces. The crystal structures suggest that the seven Sm proteins could form a closed ring and the snRNAs may be bound in the positively charged central hole. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1D3B is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CIT and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1D3B is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CIT:'>CIT</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D3B OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Avis, J | + | [[Category: Avis, J M.]] |
| - | [[Category: Fortelle, E | + | [[Category: Fortelle, E De La.]] |
[[Category: Kambach, C.]] | [[Category: Kambach, C.]] | ||
[[Category: Li, J.]] | [[Category: Li, J.]] | ||
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[[Category: systemic lupus erythematosus]] | [[Category: systemic lupus erythematosus]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:12:29 2008'' |
Revision as of 10:12, 21 February 2008
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CRYSTAL STRUCTURE OF THE D3B SUBCOMPLEX OF THE HUMAN CORE SNRNP DOMAIN AT 2.0A RESOLUTION
Contents |
Overview
The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F, and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs (snRNAs). These proteins share a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. Crystal structures of two Sm protein complexes, D3B and D1D2, show that these proteins have a common fold containing an N-terminal helix followed by a strongly bent five-stranded antiparallel beta sheet, and the D1D2 and D3B dimers superpose closely in their core regions, including the dimer interfaces. The crystal structures suggest that the seven Sm proteins could form a closed ring and the snRNAs may be bound in the positively charged central hole.
Disease
Known diseases associated with this structure: Cone dystrophy-1 OMIM:[312610], Cone-rod dystrophy OMIM:[312610], Macular degeneration, X-linked atrophic OMIM:[312610], Retinitis pigmentosa, X-linked with deafness and sinorespiratory infections OMIM:[312610], Retinitis pigmentosa, X-linked, with recurrent respiratory infections OMIM:[312610], Retinitis pigmentosa-3 OMIM:[312610]
About this Structure
1D3B is a Protein complex structure of sequences from Homo sapiens with and as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs., Kambach C, Walke S, Young R, Avis JM, de la Fortelle E, Raker VA, Luhrmann R, Li J, Nagai K, Cell. 1999 Feb 5;96(3):375-87. PMID:10025403
Page seeded by OCA on Thu Feb 21 12:12:29 2008
Categories: Homo sapiens | Protein complex | Avis, J M. | Fortelle, E De La. | Kambach, C. | Li, J. | Nagai, K. | Walke, S. | CIT | GOL | Core snrnp domain | Rna binding protein | Sle | Sm | Snrnp | Splicing | Systemic lupus erythematosus
